Recent advances in understanding endometrial receptivity: molecular basis and clinical applications

Carolina von Grothusen, Sujata Lalitkumar, Lalitkumar S, Nageswara Rao Boggavarapu, Kristina Gemzell‐Danielsson, Gemzell-Danielsson K, Kristina Gemzell-Danielsson, Lalitkumar PG, Parameswaran G Lalitkumar
American journal of reproductive immunology (New York, N.Y. : 1989) · 2014 · doi:10.1111/aji.12226 · PMID:24635108
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This review summarizes tools and molecular targets used to identify endometrial receptivity, highlighting recent advances like the endometrial receptivity array and the ongoing search for noninvasive diagnostic methods.

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Abstract

Advancement in the field of ART has lead to the possibility of achieving good quality embryos. However, the success rate in ART needs further improvement. This is largely dependent on identifying the receptive endometrium for the successful implantation of embryos as well as modulating the endometrium to the receptive stage. In the last half-a-decade, focus has been shifting toward identifying the receptive endometrium. Here, we summarize different tools explored to identify receptive endometrium from the literature, mainly focusing on the past decade, with the help of PubMed. The quest to identify endometrial receptivity markers has lead to the exploration of morphological features at micro and macro scale levels. A large number of studies at molecular levels have focused on genomic, proteomic and lipidomic targets. Recent development of endometrial receptivity array is a promising diagnostic instrument. However, a noninvasive possibility for the diagnosis of endometrial receptivity would be an ideal tool, which could be used in the clinic to improve the success rate of ART. Improved knowledge on endometrial receptivity will not only help to improve the diagnosis and treatment of infertility but will also give possibilities to develop new contraceptive methods targeting the endometrium.

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Condition tags

endometriosisinfertility

MeSH descriptors

Embryo Implantation Endometriosis Endometrium Gene Expression Regulation Infertility, Female Biomarkers Biomarkers Databases, Genetic Embryo Implantation Embryo, Mammalian Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Fertilization in Vitro Gene Expression Regulation Humans

Funding

funders
[{'doi': None, 'name': 'Swedsish research council', 'awards': ['K2010-54X-14212-09-3']}]

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (92)

Source provenance

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