Endometrial thickness is a valid monitoring parameter in cycles of ovulation induction with menotropins alone
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This study investigated the validity of endometrial thickness as a monitoring parameter during ovulation induction cycles using menotropins alone.
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Abstract
ObjectiveTo evaluate the ability of an ultrasound (US)-measured periovulatory endometrial thickness to predict conception in hMG-stimulated cycles.DesignRetrospective.SettingA university-based tertiary practice.PatientsOne hundred twelve patients undergoing 292 cycles of ovulation induction with hMG alone.Main outcome measuresA periovulatory transvaginal US measurement of endometrial thickness was obtained during cycles of ovulation induction with hMG alone. Clinical pregnancy was defined by fetal cardiac activity. Sensitivity and false-positive rates for multiple discriminatory values of endometrial thickness were calculated and a relative operating characteristic (ROC) curve was constructed to evaluate the performance of this test as a predictor of pregnancy.ResultsThirty-eight of 292 cycles resulted in pregnancy. Conception and nonconception cycles showed similar demographics, diagnoses, peak E2, maximum number of follicles, midluteal P, and mean endometrial thickness. Ovulatory dysfunction was a more frequent diagnosis in the conception group. Relative operating characteristic analysis for endometrial thickness as a predictor of pregnancy yielded an area under the curve of 0.623 +/- 0.049 (mean +/- SD).ConclusionEndometrial thickness is a valid screening test for conception outcome in cycles stimulated with hMG. A periovulatory endometrial thickness > or = 10 mm defined 91% of conception cycles. No pregnancy occurred when the endometrium measured < 7 mm.
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Cited by (20)
- Endometriosis-associated infertility: From pathophysiology to tailored treatment 2022
- Study of endometrial thickness and pregnancy outcome following induction of ovulation and intrauterine insemination in primary infertility 2020
- A differentiated approach to managing patients with the thin endometrium 2019
- Endometrial compaction (decreased thickness) in response to progesterone results in optimal pregnancy outcome in frozen-thawed embryo transfers 2019
- Comparative Evaluation of Follicular Development and Endometrial Thickness in Spontaneous and Clomiphene Citrate Induced Cycle in Unexplained Infertility 2016
- Apatient with a thin endometrium 2015
- Treating patients with “thin” endometrium – an ongoing challenge 2014
- Dilatation and Curettage Effect on the Endometrial Thickness 2013
- Endometrium in Improving IVF Outcomes: Assessing its Behavior and Making an Ally from an Enemy 2012
- A meta-analysis of the relationship between endometrial thickness and outcome of in vitro fertilization cycles 2011
- Ultrasonography of the endometrium 2010
- Pelvic Imaging in Reproductive Endocrinology 2009
- Clinical relevance of endometrial assessment 2008
- Dopplersonographie in der Resproduktionsmedizin 2007
- Extended estrogen administration for women with thin endometrium in frozen-thawed in-vitro fertilization programs 2006
- Follicular growth, endometrial thickness, and serum estradiol levels in spontaneous and clomiphene citrate-induced cycles 2003
- Minimal stimulation protocol for use with intrauterine insemination in the treatment of infertility 2002
- Subendometrial contractility is not predictive for <i>in vitro</i> fertilization (IVF) outcome 2001
- Endometrial ultrasonography as a predictor of pregnancy in an in-vitro fertilization programme after ovarian stimulation and gonadotrophin-releasing hormone and gonadotrophins 1997
- Notable Points From Recent Literature 1997
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