Minimal stimulation protocol for use with intrauterine insemination in the treatment of infertility
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This study found that a minimal stimulation protocol using clomiphene and a single hMG injection yielded pregnancy rates comparable to conventional full hMG stimulation for intrauterine insemination in infertile patients.
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Abstract
OBJECTIVE: To determine whether minimal stimulation with clomiphene and one injection of 150 IU of human menopausal gonadotrophin (hMG) provides pregnancy rates comparable with those in a conventional full hMG stimulation protocol for infertile patients undergoing intrauterine insemination (IUI). METHODS: A prospective study was carried out at the Infertility Clinic of a teaching institute and tertiary care referral center in Chandigarh, India. Two hundred couples with either unexplained infertility or ovulatory dysfunction cases who ovulated with clomiphene citrate (CC) but failed to conceive were offered ovarian stimulation with CC and hMG along with IUI for 420 cycles. Pregnancy rate, medication and monitoring cost were compared between minimal and conventional stimulation protocols. RESULTS: There was no difference in the couples of the two stimulation protocols regarding their age, duration and type of infertility as well as cause of infertility. Number of ampoules of hMG and monitoring costs were significantly higher in the full hMG stimulation cases whereas pregnancy rate was comparable in both protocols. CONCLUSION: Minimal stimulation appears to be an effective protocol in cases of unexplained infertility undergoing intrauterine insemination. Reduced cost and minimal monitoring is appealing to patients and the clinician.
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Cites (3)
- Endometrial thickness is a valid monitoring parameter in cycles of ovulation induction with menotropins alone 1996
- Menotropins alone are superior to a clomiphene citrate and menotropin combination for superovulation induction among clomiphene citrate failures 1996
- Minimal stimulation achieves pregnancy rates comparable to human menopausal gonadotropins in the treatment of infertility 1996
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References (16)
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