Endometrial thickness is a valid monitoring parameter in cycles of ovulation induction with menotropins alone

Robert H. Israel, J D Isaacs, C S Wells, John D. Isaacs, Carla S. Wells, D B Williams, R R Odem, Daniel B. Williams, Randall R. Odem, M J Gast, R C Strickler, Michael J. Gast, Ronald C. Strickler
Fertility and sterility · 1996 · vol. 65(2) , pp. 262–266 · doi:10.1016/s0015-0282(16)58082-0 · PMID:8566245 · W2395553436
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This study investigated the validity of endometrial thickness as a monitoring parameter during ovulation induction cycles using menotropins alone.

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Abstract

OBJECTIVE: To evaluate the ability of an ultrasound (US)-measured periovulatory endometrial thickness to predict conception in hMG-stimulated cycles. DESIGN: Retrospective. SETTING: A university-based tertiary practice. PATIENTS: One hundred twelve patients undergoing 292 cycles of ovulation induction with hMG alone. MAIN OUTCOME MEASURES: A periovulatory transvaginal US measurement of endometrial thickness was obtained during cycles of ovulation induction with hMG alone. Clinical pregnancy was defined by fetal cardiac activity. Sensitivity and false-positive rates for multiple discriminatory values of endometrial thickness were calculated and a relative operating characteristic (ROC) curve was constructed to evaluate the performance of this test as a predictor of pregnancy. RESULTS: Thirty-eight of 292 cycles resulted in pregnancy. Conception and nonconception cycles showed similar demographics, diagnoses, peak E2, maximum number of follicles, midluteal P, and mean endometrial thickness. Ovulatory dysfunction was a more frequent diagnosis in the conception group. Relative operating characteristic analysis for endometrial thickness as a predictor of pregnancy yielded an area under the curve of 0.623 +/- 0.049 (mean +/- SD). CONCLUSION: Endometrial thickness is a valid screening test for conception outcome in cycles stimulated with hMG. A periovulatory endometrial thickness > or = 10 mm defined 91% of conception cycles. No pregnancy occurred when the endometrium measured < 7 mm.

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MeSH descriptors

Endometrium Fertility Agents, Female Menotropins Ovulation Induction Adult Endometrium Endometrium Endometrium Female Fertility Agents, Female Humans Menotropins Monitoring, Physiologic Ovulation Induction Predictive Value of Tests Retrospective Studies ROC Curve Sensitivity and Specificity Ultrasonography

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