Proliferative Activity of Microvessels and Angiogenesis in Eutopic Endometrium in Patients with Peritoneal Endometriosis

V A Burlev, В. А. Бурлев, N A Il'yasova, N. A. Ilyasova, E D Dubinskaya
Bulletin of experimental biology and medicine · 2005 · vol. 139(6) , pp. 727–731 · doi:10.1007/s10517-005-0391-2 · PMID:16224594 · W1981645522
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-11 ⓘ

Peritoneal endometriosis is characterized by dysregulated angiogenesis in eutopic endometrium, promoted by high vascular endothelial growth factor A in peritoneal fluid, facilitating endometrial implantation.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-11 · read from full text ⓘ

The paper studied microvessel density and angiogenic activity in eutopic endometrium across different menstrual phases in patients with peritoneal endometriosis, using a comparative analysis approach. It found dysregulated angiogenesis in the eutopic endometrium, characterized by excessive microvessel proliferative activity, and linked this state to a paracrine mechanism involving high concentrations of vascular endothelial growth factor A in peritoneal fluid that can maintain angiogenesis. A key caveat is that the work is primarily observational/comparative in human endometrium, and the proposed paracrine/implantation mechanism is inferred from angiogenesis measurements rather than directly tested. This paper is centrally about endometriosis — it specifically examines angiogenesis and microvessel activity in eutopic endometrium in patients with peritoneal endometriosis.

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Abstract

Comparative analysis of the density of microvessels and angiogenic activity in eutopic endometrium during different phases of the menstrual cycle in patients with peritoneal endometriosis showed that peritoneal form of endometriosis is a paracrine disease with dysregulation of angiogenesis processes in the eutopic endometrium. Excessive angiogenesis in this condition promotes implantation of eutopic endometrium on the peritoneum. Angiogenesis in eutopic endometrium can be maintained due to high concentrations of vascular endothelial growth factor A in the peritoneal fluid. Similar content being viewed by others

References

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Condition tags

endometriosis

MeSH descriptors

Cell Division Endometriosis Endometrium Neovascularization, Pathologic Peritoneum Adult Ascitic Fluid Ascitic Fluid Biopsy Case-Control Studies Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Endometrium Female Humans Menstrual Cycle

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