Increased microvessel density in adenomyosis uteri

Monika Schindl, M Schindl, Schindl M, Birner P, Peter Birner, P Birner, Andreas Obermair, A Obermair, Ludwig Kiesel, L Kiesel, Kiesel L, René Wenzl, R Wenzl, Wenzl R
Fertility and sterility · 2001 · vol. 75(1) , pp. 131–135 · doi:10.1016/s0015-0282(00)01642-3 · PMID:11163827 · W1996622332
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This study investigated microvessel density in adenomyosis uteri and found a significant increase.

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Abstract

ObjectiveTo investigate microvessel density in adenomyosis compared to the endometrium in patients with adenomyosis and in normal controls.DesignUterine paraffin-embedded histologic specimens were immunostained for CD34. The area with the highest microvessel density in adenomyosis and in the endometrium was evaluated. All microvessels in a specific field of view (x200 magnification) were counted.SettingThe Department of Gynecological Endocrinology and the Institute of Clinical Pathology, Department of Gynecopathology, in an university hospital.Patient(s)Specimens of 53 patients with adenomyosis, who had undergone hysterectomy. Endometrial specimens of 17 women without uterine pathology were investigated as normal controls.Main outcome measure(s)Microvessel density in adenomyosis and in the endometrium.Result(s)The mean microvessel density was significantly higher in adenomyosis than in the endometrium of the same patients (33.5 +/- 14.6 vs. 19.5 +/- 12.5 microvessels/field; P<.001 sign test). No significant difference between the endometrium of patients and of normal controls was observed (P=.805).Conclusion(s)Adenomyosis exhibits angiogenic properties. However, the endometrium of patients with adenomyosis is not more prone to express angiogenic activity compared to the endometrium of normal controls.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Endometriosis Neovascularization, Pathologic Uterine Neoplasms Adult Antigens, CD34 Antigens, CD34 Capillaries Capillaries Endometriosis Endometrium Endometrium Endometrium Female Humans Immunoenzyme Techniques Neovascularization, Pathologic Regional Blood Flow Regional Blood Flow Uterine Neoplasms

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References (30)

Cited by (44)

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