Natural killer cell activity in endometriosis: correlation between serum estradiol levels and cytotoxicity.
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Natural killer cell activity significantly decreases with increasing endometriosis stage and is inversely correlated with serum estradiol levels.
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Abstract
OBJECTIVE: To evaluate the correlation between natural killer cell activity and serum estradiol (E2) levels in patients with different stages of endometriosis. METHODS: Natural killer cell activity of peripheral blood lymphocytes and serum E2 levels were evaluated in 73 women who underwent laparoscopy for pelvic pain, infertility, and benign adnexal masses. RESULTS: The 33 patients (45%) with endometriosis showed a significant decrease in natural killer cell activity in relationship to an increase in disease stage (correlation coefficient r = -0.83, P < .001). A significant inverse relationship was observed between cytotoxicity and serum E2 levels (correlation coefficient r = -0.89, P < .001). CONCLUSION: The relationship between natural killer cell activity and serum E2 levels suggests that an immunoendocrine interaction plays an important role in the progression of endometriosis.
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- Inhibitory KIR2DL2 Gene: Risk for Deep Endometriosis in Euro-descendants 2020
- Early maternal separation accelerates the progression of endometriosis in adult mice 2020
- Regulation of Inflammation Pathways and Inflammasome by Sex Steroid Hormones in Endometriosis 2020
- The Lymphatic System in Endometriosis: a Pilot Study of Endometrial-Like Cells and Immune Cell Populations in Lymph Nodes Associated with Deep Infiltrating Bowel Lesions 2020
- From Clinical Research to Clinical Practice in Obstetrics and Gynecology 2020
- Platelets impair natural killer cell reactivity and function in endometriosis through multiple mechanisms 2017
- Estrogen is an important mediator of mast cell activation in ovarian endometriomas 2017
- Platelet-derived TGF-β1 mediates the down-modulation of NKG2D expression and may be responsible for impaired natural killer (NK) cytotoxicity in women with endometriosis 2016
- Decreased Cytotoxicity of Peripheral and Peritoneal Natural Killer Cell in Endometriosis 2016
- Role of NK Cells in Endometriosis 2014
- INTEGRATIVE THERAPIE DER ENDOMETRIOSE LASER-AKUPUNKTUR UND INTRAVENÖSE LASERTHERAPIE 2014
- Roles of regulatory T cells in endometriosis-associated infertility 2014
- A Critical Review of Endometriosis Pathology 2013
- The emerging role of epigenetics in the aetiology of endometriosis. 2011
- Endometriosis in the African American woman—racially, a different entity? 2011
- Lymphocytes in Endometriosis 2010
- Evolving Spectrum: 2010
- Ursachen von Endometriose: Schlussfolgerungen aus Praxiserfahrung und Nachuntersuchung 2010
- Peripheral biomarkers of endometriosis: a systematic review 2010
- Association of HLA-A, B antigens with Susceptibility to Advanced Endometriosis in Koreans 2008
- Effect of BCG vaccine on peritoneal endometriotic implants in a rat model of endometriosis 2006
- Endometriosis: epidemiology and aetiological factors 2004
- In vitro effect of gonadotropin-releasing hormone agonist on natural killer cell cytolysis in women with and without endometriosis 2004
- Diagnosis and treatment of endometriosis 2003
- Suppression of natural killer cell activity by splenocyte transplantation in a rat model of endometriosis 2002
- Pathogenesis of Endometriosis 2002
- BCG vaccination to prevent implantation of endometriosis: an experimental study in rats 2001
- Endometriosis and unexplained recurrent spontaneous abortion: pathological states resulting from aberrant modulation of natural killer cell function? 1999
- Immunology of endometriosis 1999
- Decrease in Peripheral Blood Polymorphonuclear Leukocyte Chemotactic Index in Endometriosis: Role of Prostaglandin E2 Release 1998
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- Modulation of NK Cell Lytic Function by Endometrial Secretory Factors: Potential Role in Endometriosis 1996
- Endometriosis: Effect of endometriosis on white blood cell subpopulations in peripheral blood and peritoneal fluid of baboons 1996
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- Endometriosis: Soluble CD23 protein in the peritoneal fluid of patients with endometriosis 1996
- Pathogenesis of Infertility in Endometriosis 1995
- Relationship between 17-ß-estradiol and prolactin in the regulation of natural killer cell activity during progression of endometriosis 1995
- Leukocyte Subpopulation Changes in Rats With Autotransplanted Endometrium and the Effect of Danazol 1995
- Effect of Nei-Yi Recipe (内异方) on plasma β-endorphin level during menstrual cycle in women with endometriosis 1995
- Natural killer activity in stage III and IV endometriosis 1995
- Correlation between Estradiol Serum Levels and NK Cell Activity in Endometriosis 1994
- CO<sub>2</sub>‐laser excision of endometriosis does not improve the decreased natural killer activity 1994
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