BCG vaccination to prevent implantation of endometriosis: an experimental study in rats

Abdülaziz Gül, A Gül, Gül A, Yaşar T, Tekin Yaşar, T Yaşar, S Uğraş, Serdar Uğraş
European journal of obstetrics, gynecology, and reproductive biology · 2001 · vol. 98(2) , pp. 209–212 · doi:10.1016/s0301-2115(01)00307-4 · PMID:11574133 · W2017059263
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BCG vaccination was investigated as a preventative measure for endometriosis, with the study examining its efficacy in an experimental rat model.

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Abstract

To investigate whether BCG vaccination can prevent endometrial implantation in a rat model. Forty sexually mature virgin Wistar-Albino rats weighing 185-215g were randomly assigned (double-blind) to two groups. The first group (n=20) were injected with BCG 3 weeks before endometrial implantation to the eye. The second group (n=20) with BCG not injected before endometrial implantation was the control. Photobiomicroscopy observation was done weekly and 6 weeks post endometrial implantation all eyes were investigated histologically.Five implants grew in the anterior surface of the iris of the first (vaccinated) group and 17 in the second (control) group. The difference was statistically significant. Systemic prophylaxis with BCG can exert an inhibitory effect on endometrial transplantation.

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Condition tags

endometriosis

MeSH descriptors

BCG Vaccine Endometriosis Animals BCG Vaccine Endometriosis Endometriosis Endometrium Endometrium Female Iris Iris Rats Rats, Wistar

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