Abnormal (auto)immunity and endometriosis.

Gleicher N, N Gleicher, Norbert Gleicher, Donna Pratt, D Pratt, Pratt D
International Journal of Gynecology & Obstetrics · 1993 · vol. 40 Suppl , pp. S21–7 · PMID:8099022 · W12860578
article OA: closed CC0 ⤵ 12 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-11 ⓘ

Immunologic abnormalities may precede endometriosis and contribute to infertility and pregnancy loss, suggesting endometriosis is a systemic disease requiring novel therapeutic approaches.

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Abstract

Immunologic abnormalities may precede endometriosis and be involved in its pathophysiology especially as it relates to the occurrence of infertility and pregnancy loss. Many cases of unexplained infertility may represent undiagnosed endometriosis. This is supported by the observation that immunologic profiles in endometriosis and unexplained infertility are very similar. It is argued that endometriosis is a systemic rather than local disease, thus requiring systemic therapy. Currently available medical and surgical techniques are effective in relieving symptomatology associated with endometriosis, although this is often temporary. A new clinical approach is needed that considers systemic presentation and likely immunologic pathophysiology.

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Condition tags

endometriosisinfertility

MeSH descriptors

Autoimmune Diseases Autoimmunity Endometriosis Abortion, Spontaneous Abortion, Spontaneous Abortion, Spontaneous Autoantibodies Autoantibodies Autoimmune Diseases Autoimmune Diseases Autoimmune Diseases Danazol Danazol Endometriosis Endometriosis Endometriosis Female Humans Infertility, Female Infertility, Female

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

Cited by (12)

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