Association of HLA-A, B antigens with Susceptibility to Advanced Endometriosis in Koreans

Dong Hee Whang, Sung Hoon Kim, Myoung Hee Park, Young Min Choi
The Korean journal of laboratory medicine · 2008 · vol. 28(2) , pp. 118–123 · doi:10.3343/kjlm.2008.28.2.118 · PMID:18458507 · W2133101799
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This study compared HLA-A and B antigen distributions in Korean advanced endometriosis patients and controls, finding no significant association unlike in the Japanese population.

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This study examined whether susceptibility to advanced endometriosis in Koreans is associated with HLA-A and HLA-B antigen profiles, motivated by prior reports in Japanese populations. The researchers genotyped HLA-A and HLA-B using a PCR sequence-specific oligonucleotide hybridization method in 50 Korean patients with surgically and histologically confirmed advanced endometriosis and compared antigen distributions with 200 ethnically matched unrelated controls. B39 was more frequent in endometriosis patients than controls, but the association was not statistically significant after correction for multiple comparisons, and no significant differences were observed for other tested HLA-A/B antigens. This paper is centrally about endometriosis — it tests whether HLA-A and HLA-B antigens (notably B39) are associated with susceptibility to advanced endometriosis in a Korean population, reporting no robust association.

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Abstract

BACKGROUND: Endometriosis is defined as the presence of endometrial tissue outside the uterus, causing diverse diseases, including infertility, pelvic pain, dysmenorrhea, and constipation. While there is a growing body of evidence that genetic and immunologic factors play important roles in the pathogenesis of the disease, HLA-A, B antigens have been reported to be associated with the risk of endometriosis in the Japanese population. This study was performed to determine whether the susceptibility to advanced endometriosis is also associated with HLA-A, B antigens in the Korean population, which is the closest ethnic group to Japanese. METHODS: We recruited 50 Korean patients with advanced endometriosis confirmed by surgical and histolological examinations. Distribution of HLA-A and B antigens was compared with that of 200 unrelated ethnically matched individuals. HLA-A and B genotyping was carried out using a PCRsequence specific oligonucleotide hybridization method. RESULTS: An increased frequency of B39 was observed in endometriosis patients compared with control subjects, but the difference was not statistically significant after correcting for multiple comparisons (4.0% patients vs 0.8% controls, OR=5.5, 95% CI=1.21-25.04, P=0.03, P(c)=not significant). No significant differences were found between the patients with endometriosis and the general control group with regards to the distribution of other HLA-A and B antigens. CONCLUSIONS: The findings of the present study suggest that the susceptibility to advanced endometriosis, unlike in the Japanese population, is not associated with HLA-A, B antigens in the Korean population.
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Background

Endometriosis is defined as the presence of endometrial tissue outside the uterus, causing diverse diseases, including infertility, pelvic pain, dysmenorrhea, and constipation. While there is a growing body of evidence that genetic and immunologic factors play important roles in the pathogenesis of the disease, HLA-A, B antigens have been reported to be associated with the risk of endometriosis in the Japanese population. This study was performed to determine whether the susceptibility to advanced endometriosis is also associated with HLA-A, B antigens in the Korean population, which is the closest ethnic group to Japanese.

Methods

We recruited 50 Korean patients with advanced endometriosis confirmed by surgical and histolological examinations. Distribution of HLA-A and B antigens was compared with that of 200 unrelated ethnically matched individuals. HLA-A and B genotyping was carried out using a PCRsequence specific oligonucleotide hybridization method.

Results

An increased frequency of B39 was observed in endometriosis patients compared with control subjects, but the difference was not statistically significant after correcting for multiple comparisons (4.0% patients vs 0.8% controls, OR=5.5, 95% CI=1.21-25.04, P=0.03, Pc=not significant). No significant differences were found between the patients with endometriosis and the general control group with regards to the distribution of other HLA-A and B antigens.

Conclusions

The findings of the present study suggest that the susceptibility to advanced endometriosis, unlike in the Japanese population, is not associated with HLA-A, B antigens in the Korean population.

Keywords

HLA-A, HLA-B, Endometriosis, Susceptibility

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Condition tags

endometriosisdysmenorrheainfertility

MeSH descriptors

Endometriosis Genes, MHC Class I Genetic Predisposition to Disease HLA-A Antigens HLA-B Antigens Alleles Endometriosis Female Gene Frequency HLA-A Antigens HLA-B Antigens Humans Korea

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