Studies on the human leukocyte antigen-DR in patients with endometriosis: genotyping of HLA-DRB1 alleles

Ishii K, Keisuke Ishii, Takakuwa K, Koichi Takakuwa, Mitsui T, Takuya Mitsui, Tanaka K, Kenichi Tanaka
Human Reproduction · 2002 · vol. 17(3) , pp. 560–563 · doi:10.1093/humrep/17.3.560 · PMID:11870103 · W2167352050
article OA: closed CC0 ⤵ 21 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This study found a significantly higher incidence of the HLA-DRB1*1403 allele in patients with endometriosis compared to controls.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

BACKGROUND: An increasing number of reports suggest that endometriosis is associated with abnormal immune function involving changes in both cell-mediated and humoral immunity, although the aetiology of the disease remains undefined. The human leukocyte antigen system (HLA) is known to play a role in the aetiology of a number of diseases. This study examines the possible association between the HLA-DR and endometriosis. METHODS: Eighty-three patients diagnosed with endometriosis by laparoscopic examination were typed for HLA-DR antigens using a PCR-restriction fragment length polymorphism analysis. The frequency of HLA-DR genotypes in this patient population was compared with that in a population of general controls. RESULTS: The incidence of HLA-DRB1*1403 in the patient group was 6.0% (10/166 alleles) compared with 1.4% in the control group (6/444 alleles), and the incidence of the HLA-DRB1*1403 allele was significantly greater in patients with endometriosis compared with the control population [odds ratio 4.68, 95% confidence interval 1.67-13.09, P = 0.0013 (chi(2) analysis), (corrected P values: Pc = 0.0494)]. No significant difference was found between the two groups with regards to the frequency of the other HLA-DR alleles. CONCLUSIONS: The results from this study may be helpful to implicate a role of HLA-DR antigens in the development of endometriosis, although further investigation is required.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Alleles Endometriosis Endometriosis HLA-DR Antigens Endometriosis Female Gene Frequency Genotype HLA-DR Antigens HLA-DRB1 Chains Humans Male Reference Values

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (34)

Cited by (21)

Source provenance

europepmc
last seen: 2026-08-20T06:14:21.026120+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:13:13.417725+00:00
unpaywall
last seen: 2026-08-19T06:23:00.919175+00:00
License: CC0 · commercial use OK