Mapping of susceptibility locus for endometriosis within the HLA region using microsatellite markers in Japanese women

Matsuzaka Y, Y Matsuzaka, Yasunari Matsuzaka, Kikuti YY, Y Y Kikuti, S Izumi, Izumi S, Takahiro Suzuki, Suzuki T, T Suzuki, L-Y Cai, Cai LY, Cai Lv, Goya K, K Goya, Kenichi Goya, Inoko H, Hidetoshi Inoko, H Inoko, T Makino, Makino T, Tsunehisa Makino, Jerzy K. Kulski, J K Kulski, M Kimura, Minoru Kimura, Kimura M
Tissue antigens · 2009 · vol. 75(1) , pp. 65–67 · doi:10.1111/j.1399-0039.2009.01391.x · PMID:20196820 · W2171839420
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⚙ AI-generated summary by claude@2026-06, 2026-06-13 ⓘ

This study analyzed microsatellite markers in the human leukocyte antigen region of Japanese women and found no association with endometriosis, suggesting the HLA class II and part of class III regions are not involved in its etiology in this population.

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Abstract

Endometriosis is a female disorder characterized by the presence of uterine endometrial tissue in ectopic loci. Previous studies reported a higher prevalence of particular human leukocyte antigen (HLA) in endometriosis. In order to confirm the association between endometriosis and the HLA region, 15 polymorphic microsatellite markers distributed in the HLA class II to class III region were subjected to association analysis by polymerase chain reaction (PCR)-based DNA typing of 89 patients and 136 healthy controls. Statistical analysis of the allelic frequency at each microsatellite locus showed that there were no statistically significant differences in the allele frequency distributions between the cases and controls. This finding suggests that the etiology of endometriosis does not involve the HLA class II genomic region and a portion of class III genomic region in the Japanese population.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Genes, MHC Class II Genetic Predisposition to Disease HLA Antigens Uterine Diseases Adult Asian People Endometriosis Female Gene Frequency Genetic Association Studies HLA Antigens Humans Microsatellite Repeats Middle Aged Polymorphism, Genetic Uterine Diseases

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