Studies on the human leukocyte antigen-DR in patients with endometriosis: genotyping of HLA-DRB1 alleles

Ishii K, Keisuke Ishii, Takakuwa K, Koichi Takakuwa, Mitsui T, Takuya Mitsui, Tanaka K, Kenichi Tanaka
Human Reproduction · 2002 · vol. 17(3) , pp. 560–563 · doi:10.1093/humrep/17.3.560 · PMID:11870103 · W2167352050
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This study found a significantly higher incidence of the HLA-DRB1*1403 allele in patients with endometriosis compared to controls.

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Abstract

BACKGROUND: An increasing number of reports suggest that endometriosis is associated with abnormal immune function involving changes in both cell-mediated and humoral immunity, although the aetiology of the disease remains undefined. The human leukocyte antigen system (HLA) is known to play a role in the aetiology of a number of diseases. This study examines the possible association between the HLA-DR and endometriosis. METHODS: Eighty-three patients diagnosed with endometriosis by laparoscopic examination were typed for HLA-DR antigens using a PCR-restriction fragment length polymorphism analysis. The frequency of HLA-DR genotypes in this patient population was compared with that in a population of general controls. RESULTS: The incidence of HLA-DRB1*1403 in the patient group was 6.0% (10/166 alleles) compared with 1.4% in the control group (6/444 alleles), and the incidence of the HLA-DRB1*1403 allele was significantly greater in patients with endometriosis compared with the control population [odds ratio 4.68, 95% confidence interval 1.67-13.09, P = 0.0013 (chi(2) analysis), (corrected P values: Pc = 0.0494)]. No significant difference was found between the two groups with regards to the frequency of the other HLA-DR alleles. CONCLUSIONS: The results from this study may be helpful to implicate a role of HLA-DR antigens in the development of endometriosis, although further investigation is required.

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Condition tags

endometriosis

MeSH descriptors

Alleles Alleles Endometriosis Endometriosis HLA-DR Antigens Endometriosis Endometriosis Female Female Gene Frequency Gene Frequency Genotype Genotype HLA-DR Antigens HLA-DR Antigens HLA-DRB1 Chains HLA-DRB1 Chains Humans Humans Male

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (34)

Cited by (21)

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