{"paper_id":"d567cefc-12fc-4ed2-a3fd-e64eceeea07a","body_text":"In Vitro Activity of the Novel Tetracyclines, Tigecycline, Eravacycline, and Omadacycline, Against Moraxella catarrhalis\n2021; 41(3): 293-301\nKorean J Lab Med 2008; 28(2): 118-123\nPublished online April 1, 2008 https://doi.org/10.3343/kjlm.2008.28.2.118\nCopyright © Korean Society for Laboratory Medicine.\nDong Hee Whang, M.D.1, Sung Hoon Kim, M.D.2, Myoung Hee Park, M.D.3, Young Min Choi, M.D.4\nDepartment of Laboratory Medicine1, Seoul Paik Hospital, Inje University College of Medicine, Seoul; Department of Obstetrics and Gynecology2, College of Medicine, University of Ulsan, Asan Medical Center, Seoul; Departments of Laboratory Medicine3, and Obstetrics and Gynecology4, Seoul National University College of Medicine, Seoul, Korea\nCorrespondence to: 황 동 희\n우 100-032 서울시 중구 저동 2가 85 인제대학교 서울백병원 진단검사의학과\n전화: 02-2270-0152, Fax : 02-2270-0575\nE-mail: dhwhang@lycos.co.kr\n*본 논문은 인제대학교 학술연구조성비(2006) 보조에 의한 것임.\nReceived: July 19, 2007; Revised: January 7, 2008; Accepted: January 11, 2008\nBackground : Endometriosis is defined as the presence of endometrial tissue outside the uterus, causing diverse diseases, including infertility, pelvic pain, dysmenorrhea, and constipation. While there is a growing body of evidence that genetic and immunologic factors play important roles in the pathogenesis of the disease, HLA-A, B antigens have been reported to be associated with the risk of endometriosis in the Japanese population. This study was performed to determine whether the susceptibility to advanced endometriosis is also associated with HLA-A, B antigens in the Korean population, which is the closest ethnic group to Japanese.\nMethods : We recruited 50 Korean patients with advanced endometriosis confirmed by surgical and histolological examinations. Distribution of HLA-A and B antigens was compared with that of 200 unrelated ethnically matched individuals. HLA-A and B genotyping was carried out using a PCRsequence specific oligonucleotide hybridization method.\nResults : An increased frequency of B39 was observed in endometriosis patients compared with control subjects, but the difference was not statistically significant after correcting for multiple comparisons (4.0% patients vs 0.8% controls, OR=5.5, 95% CI=1.21-25.04, P=0.03, Pc=not significant). No significant differences were found between the patients with endometriosis and the general control group with regards to the distribution of other HLA-A and B antigens.\nConclusions : The findings of the present study suggest that the susceptibility to advanced endometriosis, unlike in the Japanese population, is not associated with HLA-A, B antigens in the Korean population.\nKeywords: HLA-A, HLA-B, Endometriosis, Susceptibility","source_license":"CC0","license_restricted":false}