Evolving Spectrum:

Jani R Jensen, Charles C Coddington
Clinical obstetrics and gynecology · 2010 · vol. 53(2) , pp. 379–388 · doi:10.1097/grf.0b013e3181db7b84 · PMID:20436314 · W2017660710
article OA: closed CC0 ⤵ 28 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This review discusses the development of endometriotic implants, noting similarities to neoplasia and the involvement of both intrinsic endometrial factors and host alterations.

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Abstract

Although the exact etiology of endometriosis is unknown, several hypotheses about its origin exist. Of these, Sampson's theory of retrograde menstruation is the most widely accepted. Multiple in-vitro and in vivo models have been developed to study endometriosis. Several key steps are required to establish an endometriotic implant: presence of ectopic endometrial glands and stroma, attachment of endometrial cells to the peritoneum, invasion into the mesothelium, and survival and growth of the ectopic tissue. Many of these steps are similar to those associated with neoplasia, and numerous biologic pathways are involved. It is likely that both intrinsic factors within the ectopic endometrium and permissive alterations within the host are important to the development of endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometrium Menstruation Disturbances Peritoneal Diseases Endometriosis Endometrium Female Humans Lymphatic System Lymphatic System Menstruation Disturbances Neovascularization, Pathologic Peritoneal Diseases Pregnancy

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (73)

Cited by (28)

Source provenance

europepmc
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License: CC0 · commercial use OK