Association of Killer Cell Immunoglobulin‐like Receptor Genotypes with Susceptibility to Endometriosis

Jo Kitawaki, Bing Xu, Hiroaki Ishihara, Michiaki Fukui, Goji Hasegawa, Naoto Nakamura, Shigeto Mizuno, Mitsuhiro Ohta, Hiroshi Obayashi, Hideo Honjo
American journal of reproductive immunology (New York, N.Y. : 1989) · 2007 · vol. 58(6) , pp. 481–486 · doi:10.1111/j.1600-0897.2007.00533.x · PMID:17997746 · W2008584752
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study found that the frequency of the KIR3DS1 genotype was lower in endometriosis patients and that inhibitory KIR/HLA-class I genotypes were more common in patients, suggesting a link between KIR polymorphisms and endometriosis susceptibility.

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Abstract

PROBLEM: Endometriosis is an immune-related chronic inflammatory disease with a polygenic predisposition. The aim of this study was to investigate whether polymorphisms in killer cell immunoglobulin-like receptors (KIRs) is responsible, in part, for genetic susceptibility to endometriosis. METHOD OF STUDY: The KIRs genotype was determined in 186 patients with endometriosis and 165 control women using polymerase chain reaction with sequence-specific primers. RESULTS: The frequency of KIR3DS1 was significantly decreased in patients compared with controls (32% versus 44%, P=0.028). KIR data were analyzed using a model comprised of three large groups, in which a gradient of activation/inhibitory potential derived from the combination of KIR and human leukocyte antigen (HLA) ligand genes was taken into account. The frequency of inhibitory KIRs/HLA-class I combination genotypes was significantly higher in patients than in controls (chi2=6.010, 2 df, P=0.0496). CONCLUSION: Our results suggest that polymorphism in KIRs may be associated with susceptibility for endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis Receptors, KIR Receptors, KIR Adult Case-Control Studies Endometriosis Female Genes, MHC Class I Genes, MHC Class I Genetic Predisposition to Disease Genotype Humans Killer Cells, Natural Killer Cells, Natural Middle Aged Polymorphism, Genetic Receptors, KIR

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