Aberrant Expression of CD95 and CD69 Molecules among CD56+ Cells in Women with Endometriosis

Audrone Eidukaite, Audronė Eidukaitė, Almantas Siaurys, Almantas Šiaurys, Vytas Tamosiunas, Vytas Tamošiūnas
American journal of reproductive immunology (New York, N.Y. : 1989) · 2006 · vol. 55(4) , pp. 276–281 · doi:10.1111/j.1600-0897.2005.00360.x · PMID:16533339 · W1963575577
article OA: closed CC0 ⤵ 13 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study found that in early endometriosis, CD56+ cells in peritoneal fluid express more CD69 and CD95, suggesting their elimination may promote disease development.

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Abstract

PROBLEM: Activated lymphocytes can be eliminated by Fas/Fas ligand (FasL)-induced cell death. Endometrial cells express FasL. The aim of our study was to determine the expression of CD56+ cells (natural killer and natural killer T cells) Fas antigen CD95 and the early activation molecule CD69 in the peritoneal fluid of women with endometriosis. METHOD: Two-colour flow cytometry was used. RESULTS: In the early stages of endometriosis, more CD56+ cells expressed CD69 and CD95 molecules when compared with the control group. However, in case of severe endometriosis the percentage of CD95+CD56+ cells in peritoneal fluid was similar to that of the control group, but the expression of CD69 molecules remained high. CONCLUSION: Because of Fas/FasL mechanisms, in the initial stages of endometriosis the activated peritoneal fluid CD56+ cells can be intensively eliminated, thus providing conditions for the survival of ectopic endometrial cells and the development of the disease.

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Condition tags

endometriosis

MeSH descriptors

Antigens, CD Antigens, Differentiation, T-Lymphocyte CD56 Antigen Endometriosis Endometriosis fas Receptor Adult Antigens, CD Antigens, Differentiation, T-Lymphocyte Ascitic Fluid Ascitic Fluid Ascitic Fluid CD56 Antigen CD69 Antigens Endometriosis Endometriosis fas Receptor Female Humans Killer Cells, Natural

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (26)

Cited by (13)

Source provenance

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