Familial risk among Japanese patients with endometriosis

Katsunori Kashima, K Kashima, Tetsuya Ishimaru, T Ishimaru, Hitoshi Okamura, H Okamura, H Suginami, K Ikuma, T Murakami, Takashi Murakami, Mitsutoshi Iwashita, M Iwashita, Kenichi Tanaka, K Tanaka
International Journal of Gynecology & Obstetrics · 2003 · vol. 84(1) , pp. 61–64 · doi:10.1016/s0020-7292(03)00340-0 · PMID:14698831 · W2003635697
article OA: closed CC0 ⤵ 39 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study found that 8.8% of Japanese endometriosis patients had sisters with the condition, indicating a relative risk of 5.7 for female siblings and suggesting a genetic factor.

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Abstract

OBJECTIVES: This study was designed to examine the prevalence of endometriosis among female siblings of patients with endometriosis in Japan. METHODS: A total of 339 patients with endometriosis were questioned about endometriosis in their sisters. The control group consisted of 284 Japanese healthy fertile women with no history of endometriosis. Similarly, the controls were interviewed about their sisters. RESULTS: We detected sisters with endometriosis in 8.8% of cases and 1.5% of the control population. The relative risk of endometriosis in female siblings was 5.7. However, a significant difference was not seen in age at diagnosis and clinical stage between patients with or without a family history of endometriosis. CONCLUSIONS: These data demonstrate a familial tendency for endometriosis and suggest that endometriosis has a genetic factor in the pathogenesis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Genetic Predisposition to Disease Adolescent Adult Case-Control Studies Endometriosis Endometriosis Female Genetic Predisposition to Disease Humans Japan Japan Middle Aged Prevalence Risk Factors Siblings Surveys and Questionnaires

Citation neighborhood

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References (19)

Cited by (39)

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