RETRACTED: Case–control study to develop and validate a questionnaire for the secondary prevention of endometriosis

Giuseppe Ricci, Elena Castelpietra, Federico Romano, Giovanni Di Lorenzo, Gabriella Zito, Luca Ronfani, Stefania Biffi, Lorenzo Monasta
PloS one · 2020 · vol. 15(3) , pp. e0230828 · doi:10.1371/journal.pone.0230828 · PMID:32226031 · PMC7105104 · W3013433024
article OA: gold CC0 RETRACTED ⤵ 7 in-corpus citations
Retraction notice. Marked retracted by OpenAlex; see publisher for the formal retraction notice.
📄 Open PDF View on OpenAlex View on PubMed View at publisher

Abstract

BACKGROUND: Endometriosis is a debilitating gynecologic disease characterized by the implantation of endometrial tissue in ectopic locations, with signs of severe and chronic inflammation. The new knowledge on endometriosis has highlighted the value of secondary prevention through the early diagnosis and treatment of lesions to reduce serious consequences, first of all, infertility and chronic pelvic pain. The purpose of this study is to assess the reliability and validity of the questionnaire, as a tool to precociously identify women with endometriosis, to prevent the progression of symptoms. METHOD: We reviewed the literature and selected risk factors, symptoms, and phenotypic traits of the women affected by endometriosis to create the questionnaire divided into 8 modules, with 47 questions. A total of 151 women completed the questionnaires: 51 patients who have endometriosis (the cases) and 100 matched women without endometriosis (the controls). After data collection, bivariate and multivariate analyses were conducted. RESULTS: We retained four of the significant variables from a step-down logistic regression, namely chronic pelvic pain, dyspareunia with VAS≥3, painful defecation, and acne, to develop a final "predictive" logistic model achieving 90.2% sensitivity and 75% specificity. CONCLUSION: Our pilot study demonstrated that the questionnaire provides a powerful tool for the secondary prevention of endometriosis.

My notes (saved in your browser only)

Outcome instruments

VAS-pain

Condition tags

endometriosischronic_pelvic_paindyspareuniainfertility

MeSH descriptors

Endometriosis Secondary Prevention Surveys and Questionnaires Adult Case-Control Studies Endometriosis Female Humans Models, Statistical Reproducibility of Results Secondary Prevention

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (55)

Cited by (7)

Source provenance

europepmc
last seen: 2026-06-11T06:19:48.454388+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:22:05.164793+00:00
License: CC0 · commercial use OK