The expression of estrogen receptors as well as GREB1, c-MYC, and cyclin D1, estrogen-regulated genes implicated in proliferation, is increased in peritoneal endometriosis

Chiara Pellegrini, Pellegrini C, Gori I, Ilaria Gori, Chahin Achtari, Hornung D, Daniela Hornung, Chardonnens E, E. Chardonnens, Eric Chardonnens, Wunder D, Dorothea Wunder, Maryse Fiche, Fiche M, Geraldine O Canny, G. Canny
Fertility and sterility · 2012 · vol. 98(5) , pp. 1200–1208 · doi:10.1016/j.fertnstert.2012.06.056 · PMID:22884659 · W2114726691
article OA: bronze CC0 ⤵ 92 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-06 ⓘ

In peritoneal endometriosis, the expression of estrogen receptors and estrogen-regulated proliferation genes GREB1, c-MYC, and cyclin D1 is elevated.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

ObjectiveTo analyze the expression of estrogen receptors α and β as well as their target genes implicated in proliferation, c-myc, cyclin D1, and GREB1, in the endometrium of women with or without endometriosis.DesignExpression analysis in human tissue.SettingUniversity hospitals and a clinic.Patient(s)Ninety-one premenopausal women (59 patients with endometriosis and 32 controls) undergoing laparoscopic surgery.Intervention(s)Biopsies were obtained at time of surgery, performed during the proliferative phase of the cycle.Main outcome measure(s)Estrogen receptors α and β as well as c-myc, cyclin D1, and GREB1 mRNA expression levels were determined by quantitative reverse transcriptase-polymerase chain reaction. Tissue localization of these estrogen-regulated genes was analyzed by immunohistochemistry.Result(s)Estrogen receptors α and β as well as c-myc, cyclin D1, and GREB1 mRNA expression levels were increased in ectopic tissue in comparison with both normal and eutopic endometrium. Estrogen receptor mRNA levels also were upregulated in the eutopic peritoneal tissue of patients with endometriosis. Cyclin D1 and GREB1 expression was augmented in eutopic endometrium. c-myc, cyclin D1, and GREB1 proteins exhibited a nuclear localization in ectopic endometrial tissue.Conclusion(s)This constitutes the first report of increased expression of GREB1, as well as cyclin D1 and c-myc, in peritoneal endometriotic lesions, implicating these proteins in estrogen-dependent growth in this context.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Cell Proliferation Choristoma Cyclin D1 Endometriosis Endometrium Estrogen Receptor alpha Estrogen Receptor beta Neoplasm Proteins Peritoneal Diseases Proto-Oncogene Proteins c-myc Adult Biopsy Case-Control Studies Choristoma Choristoma Choristoma Choristoma Cyclin D1 Cyclin D1 Endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (69)

Cited by (50)

Source provenance

europepmc
last seen: 2026-08-14T06:11:53.302379+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:16:04.919516+00:00
License: CC0 · commercial use OK