The Comparison of Er α Expression Between Endometriosis with No Endometriosis

D. Irsat Syafardi, Hendry Salim Siregar, Yostoto B Kaban, Edy Ardiansyah
In: Sumatera Medical Journal · 2019 · vol. 2(1) , pp. 15–21 · doi:10.32734/sumej.v2i1.714 · W2921704320
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-29 ⓘ

This study examined ER α expression in ectopic and normal endometrium via immunohistochemistry and found significant differences, with ER α being more dominant in normal endometrium.

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⚙ AI-generated deep summary by claude@2026-07, 2026-07-10 · read from full text ⓘ

This cross-sectional study compared estrogen receptor alpha (ERα/REα) expression using immunohistochemistry in ectopic tissue from endometriosis cases versus normal endometrium, using samples collected from November 2015 until completion. The authors analyzed differences in ERα expression between groups with Fisher Exact test, considering p<0.05 significant. They report that ERα expression is more dominant in normal endometrium, while endometriosis tissues showed many negative ERα expressions, and they conclude there is a difference in ERα expression between endometriosis and no endometriosis, without detailing additional limitations in the abstract. This paper is centrally about endometriosis — it directly compares ERα expression in endometriosis versus non-endometriosis tissues.

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Abstract

Estrogen receptors (ER) play an important role in mediating action. The ER α has a higher affinity for estrogen and the dominant form of the normal endometrium. A cross-sectional study from an ectopic tissue of endo-metriosis and normal was examined for immunohistochemistry. This research was conducted from November 2015 until the sample complete. The analysis was performed using Fisher Exact test, p <0.05 was considered to any difference of estrogen alpha receptor expression between endometriosis patients with no endometriosis. REα is more dominant in normal endometrium, whereas in the case of endometriosis in the presence of many negative expression of REα then the assumption that REβ is a receptor that many encountered. There is a dif-ference in the expression of REα between endometriosis with no endometriosis.
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The Comparison of Er α Expression Between Endometriosis with No Endometriosis DOI: https://doi.org/10.32734/sumej.v2i1.714Keywords: Estrogen α receptor, endometriosis, normal endometriumAbstract Estrogen receptors (ER) play an important role in mediating action. The ER α has a higher affinity for estrogen and the dominant form of the normal endometrium. A cross-sectional study from an ectopic tissue of endo-metriosis and normal was examined for immunohistochemistry. This research was conducted from November 2015 until the sample complete. The analysis was performed using Fisher Exact test, p <0.05 was considered to any difference of estrogen alpha receptor expression between endometriosis patients with no endometriosis. REα is more dominant in normal endometrium, whereas in the case of endometriosis in the presence of many negative expression of REα then the assumption that REβ is a receptor that many encountered. There is a dif-ference in the expression of REα between endometriosis with no endometriosis.

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endometriosis

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last seen: 2026-06-10T17:14:06.276822+00:00
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