p16, retinoblastoma (pRb), and cyclin D1 protein expression in human endometriotic and adenomyotic lesions

Goumenou AG, Anastasia G. Goumenou, Matalliotakis IM, Ioannis M Matalliotakis, Ioannis Matalliotakis, Tzardi M, Maria Tzardi, Fragouli IG, Ivoni Fragouli, Ivoni G Fragouli, Neal G Mahutte, Neal Mahutte, Mahutte NG, Arici A, Aydın Arıcı, Aydin Arici
Fertility and sterility · 2006 · vol. 85 , pp. 1204–1207 · doi:10.1016/j.fertnstert.2005.11.032 · PMID:16616093 · W2009599997
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This study analyzed the protein expression of p16, retinoblastoma (pRb), and cyclin D1 in human endometriotic and adenomyotic lesions.

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Abstract

ObjectiveTo investigate the expression of p16, retinoblastoma (pRb), and cyclin D1 oncoproteins in endometriomas and adenomyosis.DesignImmunohistochemical study for p16, pRb, and cyclin D1 proteins in formalin-fixed paraffin-embedded endometriotic and adenomyotic tissues.SettingUniversity hospital.Patient(s)Tissues from 25 women with endometriomas and 31 women with adenomyosis were evaluated.Intervention(s)Tissue samples were collected during gynecologic surgery and confirmed by histology to have endometriosis or adenomyosis. Nuclear expression of p16, pRb, and cyclin D1 proteins was examined by immunohistochemistry.Main outcome measure(s)Distribution and intensity of immunostaining.Result(s)In the proliferative phase of the cycle, p16 was detected in 77% of adenomyosis tissues but in only 15% of endometriosis tissues. Moreover, in adenomyosis samples positive for p16, 100% of the adenomyotic cells expressed p16, whereas only 10%-20% of endometriosis cells from positive cases expressed p16. In contrast, pRb was detected in 28% of endometriosis cases but not in any adenomyotic tissues. Cyclin D1 was absent in both endometriotic and adenomyotic tissue samples.Conclusion(s)Differences in oncoprotein expression between endometriotic and adenomyotic tissues provide further evidence that the pathogenesis of endometriosis is different from that of adenomyosis.

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Condition tags

endometriosis

MeSH descriptors

Adenovirus E1A Proteins Cell Nucleus Cyclin-Dependent Kinase Inhibitor p16 Endometriosis Adenovirus E1A Proteins Adult Cell Cycle Proteins Cell Nucleus Cyclin D1 Cyclin-Dependent Kinase Inhibitor p16 Endometriosis Female Gene Expression Regulation Humans Middle Aged Nuclear Proteins Repressor Proteins Tissue Distribution

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