Involvement of estrogen receptor-related receptors in human ovarian endometriosis

Aldo Cavallini, Cavallini A, Leonardo Resta, Anna Maria Caringella, Caringella AM, Edoardo Di Naro, Edoardo Dinaro, Catia Lippolis, Lippolis C, Giuseppe Loverro
Fertility and sterility · 2011 · vol. 96(1) , pp. 102–106 · doi:10.1016/j.fertnstert.2011.04.032 · PMID:21561608 · W2052302144
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This study investigated the role of estrogen receptor-related receptors (ERRs) in human ovarian endometriosis, examining their involvement in the development and progression of the disease.

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Abstract

ObjectiveTo determine whether decreased estrogen receptor alpha (ER-α) expression in endometriotic lesions could be balanced by an increased expression of estrogen receptor-related receptors (ERRs). To evaluate whether ERR-α expression is influenced by hormonal change in fertile and menopausal women.DesignProspective controlled study.SettingUniversity Hospital, Department of Gynecology.Patient(s)Twenty-five women: 20 women of reproductive age with (n = 10) and without (control; n = 10) endometriosis and 5 menopausal women.Intervention(s)Real-time polymerase chain reaction (qPCR). Immunohistochemistry.Main outcome measure(s)The ER and ERR expression levels were studied by reverse transcriptase-qPCR, ELISA, and immunohistochemistry using endometriotic and normal endometrial tissues. The ERR-α protein distribution was performed by immunohistochemistry in fertile and menopausal women.Result(s)Increased levels of ER-β were associated with ER-α, ERR-α, and ERR-γ reductions in ectopic tissue but not in eutopic and normal endometria. Similar levels of ERR-β were found in women with and without endometriosis. The ERR-α expression was similar in proliferative and secretory endometrial samples, whereas a down-regulation of this receptor was found in atrophic tissue.Conclusion(s)Our data confirm the up-regulation of ER-β as the principal receptor involved in the progression of human endometriosis. In addition, we found that ERR-α seems to be unresponsive to hormonal changes during the menstrual cycle.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Estrogen Receptor beta Ovarian Cysts Adult Disease Progression Endometriosis Endometriosis Estrogen Receptor beta Estrogen Receptor beta Female Humans Male Ovarian Cysts Ovarian Cysts Prospective Studies Up-Regulation Up-Regulation Young Adult

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