Giuseppe Loverro

Infertility is a medical and social condition that affects millions of women worldwide and is today considered so far as a new disease. A considerable progress has been recently pursued in the field of the reproductive medicine and the infe…

ObjectiveTo determine whether decreased estrogen receptor alpha (ER-α) expression in endometriotic lesions could be balanced by an increased expression of estrogen receptor-related receptors (ERRs). To evaluate whether ERR-α expression is i…

ObjectiveTo investigate the role of adjuvant treatment with gonadotropin-releasing-hormone agonist (GnRHa) following conservative surgical treatment of endometriosis.Study designSixty patients in the reproductive age (mean age 28.6 years), …

Endometriosis is an estrogen-correlated benign disease characterized by a marked ability of endometrial-like cells to invade and proliferate outside uterine cavity, resembling for some invasive aspect the cancer growth. The molecular mechan…

BACKGROUND: Changes in angiogenesis and expression of extracellular matrix-degrading enzymes have been substantiated in tumour changeover and progression. METHODS: Tissues from 44 biopsies of stage III and IV ovarian endometriomas, and 10 b…

This study aimed to evaluate the effects of changes in sex hormones occurring during the menstrual cycle on the redox balance and lipid peroxidation in normal human endometrial cells. Forty women, ages 21-41 yr, who were admitted to the Dep…

Increased concentrations of TGF-beta 1 in endometriotic tissue are considered important in the pathophysiology of endometrial diseases since TGF-beta 1 may inhibit natural killer activity and induce angiogenesis and proliferation of endomet…

Primary cutaneous endometriosis is uncommon. The authors report a case of spontaneous umbilical endometriosis in a young woman. Clinical diagnosis was based on the observation of an umbilical bluish nodule with cyclical pain and bloody disc…

OBJECTIVES: To evaluate the diagnostic accuracy of transvaginal sonography (TVS) in detecting uterine cavity abnormalities in infertile patients, with reference to hysteroscopy as the gold standard method. STUDY DESIGN: At the Institute of…

Perforation of the sigmoid colon in a 28-year-old woman during the 35th week of pregnancy is reported. The patient was admitted for crampy lower abdominal pain, and fetal distress observed on cardiotocography led to the decision of an emerg…

ObjectivesEndometrial cells may synthetize cytokines and growth factors which may modulate some of the molecular mechanisms of endometrial proliferation and differentiation.Patients and methodsWe investigated the role of transforming growth…

Changes in prostaglandins, vascular reactivity, fibrinolytic system, or other autocrine and paracrine uterine factors are presumed to play an important role in the pathogenesis of dysfunctional uterine bleeding (DUB). Here we report the hys…

Hysteroscopy is a reliable procedure not only for diagnosis, but also for office treatment of uterine pathologies that, until recently, required general or at least topical anesthesia. The vaginoscopic approach without a speculum and tenacu…