Detection of mitochondrial biomarkers in eutopic endometria of endometriosis using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry

Ding X, Xiaoyan Ding, Wang L, Liang Wang, Yuefang Ren, Ren Y, Zheng W, Wei Zheng
Fertility and sterility · 2010 · vol. 94(7) , pp. 2528–2530 · doi:10.1016/j.fertnstert.2010.04.054 · PMID:20627238 · W2033939941
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This study utilized surface-enhanced laser desorption/ionization time-of-flight mass spectrometry to detect mitochondrial biomarkers in eutopic endometria of women with endometriosis.

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Abstract

ObjectivesTo detect specific mitochondrial proteins in eutopic endometrial samples from women with and without endometriosis and to build diagnostic models.DesignEutopic endometrial samples from women with endometriosis (excluding adenomyosis) and women with benign indications as control were studied by using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry protein-chip technology. After finding the biomarkers, the diagnostic model was evaluated and validated by leave-one cross-validation.SettingCollaborative investigation in an academic research environment.Patient(s)Twenty-four patients with endometriosis (excluding adenomyosis) and 29 patients with benign indications as control.Intervention(s)Surgical excision of eutopic endometrial biopsy of patients with endometriosis and controls.Main outcome measure(s)Mitochondrial protein expression.Result(s)Seventy-eight qualified mitochondrial protein peaks were detected, ten of them had a significant difference. Three combined potential biomarkers, with mass-to-charge ratios (m/z) of 15,334, 15,128, and 16,069, were found, and the diagnostic system distinguished endometriosis from control samples with a specificity of 86.2% and a sensitivity of 87.5%.Conclusion(s)We discovered potential mitochondrial biomarkers of eutopic endometrium in endometriosis and set up a diagnostic model. Further identification of the proteins we found will help to explain pathology, new diagnoses, and therapeutic approaches for endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Biomarkers Endometriosis Endometrium Mitochondria Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Uterine Diseases Adult Biomarkers Biomarkers Case-Control Studies Diagnostic Techniques, Obstetrical and Gynecological Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Humans Mitochondria

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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