Proteomic Biomarkers for Endometriosis

Amelie Fassbender, Antoine Hubert, Etienne Waelkens, O Dorien, Thomas D’Hooghe
In: Biomarkers for Endometriosis · 2017 · pp. 185–198 · doi:10.1007/978-3-319-59856-7_10 · W2757855750
book-chapter OA: closed CC0 ⤵ 2 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

This review discusses proteomics technologies and biomarker results for endometriosis, aiming for a non- or semi-invasive diagnostic test, as current diagnosis relies on laparoscopy.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This chapter reviews proteomics approaches for endometriosis biomarker discovery, focusing on key technologies such as SELDI-TOF mass spectrometry and 2D DIGE and critically describing findings reported across studies. It discusses the biological context of endometriosis (ectopic endometrial-like tissue, estrogen dependence, and diagnosis by laparoscopy) and summarizes that, despite proteomics detecting differentially expressed proteins/peptides, no non- or semi-invasive proteomics-based diagnostic test has been established. A major limitation emphasized is that biomarker results have not yet translated into a reliable clinical test, and the chapter frames its purpose as technology appraisal and critical interpretation of existing evidence. This paper is centrally about endometriosis — it is a proteomics biomarker review chapter evaluating methods and reported biomarker candidates for endometriosis diagnosis.

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endometriosis

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last seen: 2026-06-10T17:14:06.276822+00:00
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