Identification of biomarkers for endometriosis in plasma from patients with endometriosis using a proteomics approach

Jin-Hee Hwang, Jinhee Hwang, Kyu-Sup Lee, Kyu Sup Lee, Jong Kil Joo, Jong-Kil Joo, Tao Wang, Jung-Bin Son, Jong-Ha Park, Dae-Youn Hwang, Dae‐Youn Hwang, Man-Ho Choi, Hong-Gu Lee, Hong‐Gu Lee
Molecular medicine reports · 2014 · vol. 10(2) , pp. 725–730 · doi:10.3892/mmr.2014.2291 · PMID:24889313 · W2080227706
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This proteomics study identified haptoglobin as a significantly decreased protein in the plasma of patients with endometriosis and in mice with surgically induced endometriosis, suggesting it as a potential diagnostic biomarker.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

This study aimed to identify plasma protein biomarkers for the diagnosis of endometriosis using a proteomics workflow that combined two-dimensional electrophoresis and mass spectrometry. Plasma from 15 women with histologically confirmed endometriosis and 15 controls without endometriosis was analyzed, and candidate proteins were further validated in additional plasma from mice with surgically induced endometriosis. Among seven spots corresponding to six differentially expressed proteins, only haptoglobin (Hp) was significantly decreased in both humans and the mouse model (P<0.05). A key limitation is the small sample size and reliance on proteomic spot differences that yielded a single significant candidate. This paper is centrally about endometriosis — it focuses on identifying a blood/plasma biomarker (haptoglobin) using proteomics for endometriosis diagnosis.

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Abstract

The present study aimed to examine potential biomarkers for the diagnosis of endometriosis. A plasma-based proteomic approach, including 2-dimentional electrophoresis and mass spectrometry, was used. Samples were obtained from patients with (n=15) and without (n=15) endometriosis, or from mice with surgically induced endometriosis. Seven spots corresponding to six differentially expressed proteins were identified in the human plasma samples. However, only haptoglobin (Hp) was identified to be significantly decreased in the plasma levels of patients with endometriosis (P<0.05) and in mice with surgically induced endometriosis (P<0.05). The results demonstrated that Hp was downregulated in females with endometriosis, and it therefore, may be a useful diagnostic tool as a biomarker of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Biomarkers Endometriosis Proteomics Adult Animals Biomarkers Disease Models, Animal Down-Regulation Electrophoresis, Gel, Two-Dimensional Endometriosis Endometriosis Endometriosis Female Haptoglobins Haptoglobins Humans Mice Mice, Inbred BALB C Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Uterus

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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