Hormones and Inflammation: An Update on Endometriosis

Dora Pavone, Irene Turrini, Flavia Sorbi, Silvia Vannuccini, Tommaso Capezzuoli, Massimiliano Fambrini, Felice Petraglia
In: ISGE Series · 2019 · pp. 177–192 · doi:10.1007/978-3-030-14358-9_14 · W2956033221
book-chapter OA: closed CC0 ⤵ 1 in-corpus citation
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

This chapter examines hormonal, immunological, and inflammatory pathways in endometriosis pathogenesis, including increased estrogen activity, progesterone resistance, stress hormones, and immune factors contributing to pain and comorbidities.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This chapter updates the biology of endometriosis by integrating evidence on hormonal, immunological, and inflammatory pathways, focusing on how estrogen activity, progesterone resistance, and stress hormones intersect with dysregulated immune signaling and inflammatory mediators such as cytokines, chemokines, and prostaglandins. It describes key mechanistic findings that increased estrogen drives proliferation of both eutopic and ectopic tissue, while aberrant progesterone signaling contributes to resistance, and it highlights that cell-mediated immune processes are linked to endometriosis-associated pain. A major limitation is that this is a narrative update rather than a single primary study, so it does not provide new experimental population data or quantify effect sizes. This paper is centrally about endometriosis — it reviews hormonal and inflammatory dysregulation, including progesterone resistance and stress hormone–immune interactions, in the pathogenesis of endometriosis.

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endometriosis

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last seen: 2026-06-10T17:14:06.276822+00:00
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