Familial Risk Among Patients with Endometriosis

Rosana Maria dos Reis, R M dos Reis, Marcos Felipe Silva de Sá, de Sá MF, M F de Sá, Marcos Dias de Moura, M D de Moura, de Moura MD, A A Nogueira, Antônio Alberto Nogueira, Nogueira AA, J U Ribeiro, Ribeiro JU, João Ulisses Ribeiro, E S Ramos, Ester Silveira Ramos, R A Ferriani, Ferriani RA, Rui Alberto Ferriani
Journal of assisted reproduction and genetics · 1999 · vol. 16(9) , pp. 500–503 · doi:10.1023/a:1020559201968 · PMID:10530406 · PMC3455623 · W1578274906
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This study analyzed 101 endometriosis patients and found a higher prevalence of the disorder among their first-, second-, and third-degree relatives compared to a control group.

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This study examined the prevalence of endometriosis among first-, second-, and third-degree relatives of 101 women with confirmed endometriosis who underwent laparoscopy and/or laparotomy at two public hospitals, compared with a control group of 43 women who had laparoscopy without a diagnosis. Investigators identified families with a positive history of endometriosis among the affected patients but found no such cases among controls, with nine affected families detected (including mothers, sisters, aunts, and cousins). The authors conclude the findings support a familial tendency and suggest a genetic basis, while the key caveat is the limited sample size and the hospital-based recruitment. This paper does not explicitly discuss adenomyosis, and it is centrally about endometriosis — familial risk among relatives of patients with confirmed endometriosis.

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Abstract

PurposeThe objective of the present study was to determine the prevalence of endometriosis among the relatives of patients with confirmed endometriosis.MethodsWe analyzed the prevalence of endometriosis among first-, second-, and third-degree relatives in a group of 101 patients with varying symptoms related to endometriosis seen at two public hospitals and submitted to laparoscopy and/or laparotomy. The control group consisted of 43 women submitted to laparoscopy without a diagnosis of endometriosis.ResultsAmong the patients with endometriosis, we detected nine families with a positive history of endometriosis, comprising one mother, six sisters, three aunts, and two cousins, as opposed to no case among the controls.ConclusionsThese data confirm a familial tendency for endometriosis and suggest that this disorder has a genetic basis.
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Abstract

Purpose: The objective of the present study was to determine the prevalence of endometriosis among the relatives of patients with confirmed endometriosis.

Methods

We analyzed the prevalence of endometriosis among first-, second-, and third-degree relatives in a group of 101 patients with varying symptoms related to endometriosis seen at two public hospitals and submitted to laparoscopy and/or laparotomy. The control group consisted of 43 women submitted to laparoscopy without a diagnosis of endometriosis.

Results

Among the patients with endometriosis, we detected nine families with a positive history of endometriosis, comprising one mother, six sisters, three aunts, and two cousins, as opposed to no case among the controls.

Conclusions

These data confirm a familial tendency for endometriosis and suggest that this disorder has a genetic basis. Similar content being viewed by others

References

Ranney B: Endometriosis. IV. Hereditary tendency. Obstet Gynecol 1971;37:734-737 Simpson JL, Elias S, Malinak LR, Buttram TR: Heritable aspects of endometriosis. Am J Obstet Gynecol 1980;137:327-331 Lamb RNK, Hoffmann R, Nichols TR: Family trait analysis: A case-control study of 43 women with endometriosis and their best friends. Am J Obstet Gynecol 1986;154:596-601 Moen MH, Magnus P: The familial risk of endometriosis. Acta Obstet Gynecol Scand 1993;72:560-564 Kennedy SH, Mardon HJ, Barlow DH: The Oxford endometriosis gene study. In Abstracts of the 2nd International Meeting of the BFS, Glasgow, 1994, p 11 ASRM: Revised American Society for Reproductive Medicine classification of endometriosis: 1996. Fertil Steril 1997;67:817-820 Donadio N, Nobrega AC: Leiomyomata plus endometriosis: Simultaneous treatment with gestrinone and buserelin acetate before in vitro fertilization-embryo transfer. In Progress in the Management of Endometriosis, EM Coutinho, P Spinola, LH Moura (eds). London, New York, Parthenon, 1995, pp 135-137 Arnold LL, Meck JM, Simon JA: Adenomyosis: Evidence for genetic cause. Am J Med Genet 1995;55:505-506 Pandis N, Karaikos C, Bardi G, Sfikas K, Tserkezoglou A, Fotiou S, Heim S: Chromosome analysis of uterine adenomyosis. Cancer Genet Cytogenet 1995;80:118-120 Oziaik YY, Meloni Am, Surti U, Sandberg AA: Deletion 7q22 in uterine leiomyoma. A cytogenetic review. Cancer Genet Cytogenet 1993;71:1-6 Moen MH: Endometriosis in monozygotic twins. Acta Obstet Gynecol Scand 1994;73:59-62 Author information Authors and Affiliations Rights and permissions About this article Cite this article Dos Reis, R.M., Silva De Sá, M.F., De Moura, M.D. et al. Familial Risk Among Patients with Endometriosis. J Assist Reprod Genet 16, 500–503 (1999). https://doi.org/10.1023/A:1020559201968 Issue date: DOI: https://doi.org/10.1023/A:1020559201968

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Adult Endometriosis Female Humans Middle Aged Pedigree Prevalence Risk Assessment

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