RETRACTED: Overexpressed miR-106b-5p promotes epithelial-mesenchymal transition in endometriosis by targeting PTEN

Fen Hu, Wang Yong-lian, Yonglian Wang, Xueqing Wu, Shan Liu, Haiying Ren, Wenhui Zhou
Reproductive toxicology (Elmsford, N.Y.) · 2022 · vol. 113 , pp. 62–70 · doi:10.1016/j.reprotox.2022.07.007 · PMID:35902026 · W4287448815
article OA: hybrid CC0 RETRACTED ⤵ 2 in-corpus citations
Retraction notice. Marked retracted by OpenAlex; see publisher for the formal retraction notice.
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This study found that elevated miR-106b-5p in endometriosis promotes proliferation, migration, and EMT in human endometrial stromal cells by targeting PTEN.

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Abstract

The miRNA miR-106b-5p expression is elevated in endometriotic lesions. This study aimed to detect miR-106b-5p expression in human endometrial stromal cells and explore the molecular mechanisms regulating proliferation, migration, and epithelial-mesenchymal transition (EMT) of these cells. Cell proliferation, migration, and EMT were compared after miR-106b-5p upregulation. The downstream target of miR-106b-5p was verified using bioinformatic, luciferase reporter, and rescue assays. The relationship between miR-106b-5p and the target genes was also analyzed. Results showed that the expression of miR-106b-5p in endometriotic lesions was higher than that in non-lesion tissues. Furthermore, upregulation of miR-106b-5p promoted the proliferation, migration, and EMT of human endometrial stromal cells. Additionally, phosphatase and tensin homolog ten (PTEN) was found to be negatively correlated with miR-106b-5p expression. Low expression levels of PTEN were significantly correlated with cell proliferation, migration, and EMT. High PTEN expression could rescue the effect of miR-106b-5p on cell capacity. In conclusion, miR-106b-5p modified human endometrial stromal cell function by sponging PTEN. These findings indicate that inhibition of miR-106b-5p may be an effective therapeutic strategy for endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Epithelial-Mesenchymal Transition Epithelial-Mesenchymal Transition Epithelial-Mesenchymal Transition Epithelial-Mesenchymal Transition Epithelial-Mesenchymal Transition Epithelial-Mesenchymal Transition Epithelial-Mesenchymal Transition MicroRNAs MicroRNAs MicroRNAs MicroRNAs MicroRNAs

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References (27)

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