Familial risk among Japanese patients with endometriosis

Kashima K, Katsunori Kashima, K Kashima, T. Ishimaru, Ishimaru T, Tetsuya Ishimaru, Okamura H, H Okamura, Hitoshi Okamura, H. Suginami, Suginami H, K Ikuma, Ikuma K, T Murakami, Murakami T, Takashi Murakami, Mitsutoshi Iwashita, Iwashita M, M. Iwashita, Tanaka K, K. Tanaka, Kenichi Tanaka
International Journal of Gynecology & Obstetrics · 2003 · vol. 84(1) , pp. 61–64 · doi:10.1016/s0020-7292(03)00340-0 · PMID:14698831 · W2003635697
Observational OA: closed CC0 ⤵ 39 in-corpus citations
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This study found that 8.8% of Japanese endometriosis patients had sisters with the condition, indicating a relative risk of 5.7 for female siblings and suggesting a genetic factor.

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Abstract

OBJECTIVES: This study was designed to examine the prevalence of endometriosis among female siblings of patients with endometriosis in Japan. METHODS: A total of 339 patients with endometriosis were questioned about endometriosis in their sisters. The control group consisted of 284 Japanese healthy fertile women with no history of endometriosis. Similarly, the controls were interviewed about their sisters. RESULTS: We detected sisters with endometriosis in 8.8% of cases and 1.5% of the control population. The relative risk of endometriosis in female siblings was 5.7. However, a significant difference was not seen in age at diagnosis and clinical stage between patients with or without a family history of endometriosis. CONCLUSIONS: These data demonstrate a familial tendency for endometriosis and suggest that endometriosis has a genetic factor in the pathogenesis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Genetic Predisposition to Disease Adolescent Adolescent Adult Adult Case-Control Studies Case-Control Studies Endometriosis Endometriosis Endometriosis Female Female Genetic Predisposition to Disease Genetic Predisposition to Disease Humans Humans Japan Japan Japan

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (19)

Cited by (38)

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