Significance of Ki67 expression in endometriosis for infertility

Elvin Piriyev, Gertz MM, Mona Mariella Gertz, Sven Schiermeier, Schiermeier S, Römer T, Thomas Römer
European journal of obstetrics, gynecology, and reproductive biology · 2022 · vol. 272 , pp. 73–76 · doi:10.1016/j.ejogrb.2022.03.019 · PMID:35290875 · W4220670113
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This retrospective analysis of 670 endometriosis cases found that high Ki67 expression correlated with significantly higher postoperative pregnancy rates compared to intermediate and low expression.

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Abstract

ObjectiveThe aim of the study was to show the significance of Ki67 expression in endometriosis for infertility.Study designIt was a retrospective analysis. 670 cases were analyzed. In 484 cases, immunohistochemical proliferation analysis was performed to determine the expression of Ki67. The indicated percentages of Ki67 expression were divided into three groups. An expression below 10% is considered low, 10-30% intermediate, and over 30% is considered high.ResultsThere was a significant correlation between Ki67 expression and postoperative pregnancy onset: 66,7% of patients with high proliferation activity became pregnant within one year postoperatively, whereas the 38,7% of patients with moderate and only 17,3% of patients with low Ki67 expression became pregnant.ConclusionIn this work, high Ki67 expression was more frequent than low Ki67 expression in women with infertility than in patients without infertility. These results contribute to the importance of endometrial resection in the context of infertility treatment.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Infertility, Female Infertility, Female Infertility, Female Infertility, Female Infertility, Female Infertility, Female Infertility, Female Infertility, Female Ki-67 Antigen Ki-67 Antigen Ki-67 Antigen Ki-67 Antigen

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (15)

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