Endometriosis phenotypes are associated with specific serum metabolic profiles determined by proton-nuclear magnetic resonance

Chloé Maignien, Maignien C, Santulli P, Piétro Santulli, Pietro Santulli, Kateb F, Fatiha Kateb, Cédric Caradeuc, Louis Marcellin, Marcellin L, Pocate-Cheriet K, Khaled Pocate-Cheriet, Bourdon M, Mathilde Bourdon, Chouzenoux S, Sandrine Chouzenoux, Frédéric Batteux, Batteux F, Gildas Bertho, Chapron C, Charles Chapron
Reproductive biomedicine online · 2020 · vol. 41(4) , pp. 640–652 · doi:10.1016/j.rbmo.2020.06.019 · PMID:32839101 · W3039641843
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Proton-nuclear magnetic resonance spectroscopy identified distinct serum metabolic profiles associated with different endometriosis phenotypes in women.

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Abstract

Research questionWhat is the correlation between serum metabolic profile and endometriosis phenotype?DesignA pilot study nestled in a prospective cohort study at a university hospital, including 46 patients with painful endometriosis who underwent surgery and 21 controls who did not have macroscopic endometriotic lesions. Endometriosis was strictly classified into two groups of 23 patients each: endometrioma (OMA) and deep infiltrating endometriosis (DIE). Serum samples were collected before surgery for metabolomic profiling based on proton-nuclear magnetic resonance spectroscopy in combination with statistical approaches. Comparative identification of the metabolites in the serum from endometriosis patients and from controls was carried out, including an analysis according to endometriosis phenotype.ResultsThe serum metabolic profiles of the endometriosis patients revealed significantly lower concentrations of several amino acids compared with the controls, whereas the concentrations of free fatty acids and ketone bodies were significantly higher. The OMA and the DIE phenotypes each had a specific metabolic profile, with higher concentrations of two ketone bodies in the OMA group, and higher concentrations of free fatty acids and lipids in the DIE group.ConclusionProton-nuclear magnetic resonance-based metabolomics of serum samples were found to have ample potential for identifying metabolic changes associated with endometriosis phenotypes. This information may improve our understanding of the pathogenesis of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Fatty Acids, Nonesterified Adult Case-Control Studies Endometriosis Fatty Acids, Nonesterified Female Humans Magnetic Resonance Spectroscopy Metabolome Phenotype Pilot Projects Prospective Studies

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