Endométriose : l’augmentation des concentrations d’interleukine-1β et d’interleukine-1sRII dans le sérum est associée à la forme profonde de cette pathologie

S Lambert, Lambert S, Simon A. Lambert, P Santulli, Piétro Santulli, Santulli P, S. Chouzenoux, Chouzenoux S, Sandrine Chouzenoux, Marcellin L, L Marcellin, Louis Marcellin, Bruno Borghese, B Borghese, Dominique de Ziegler, de Ziegler D, D. de Ziegler, Frédéric Batteux, F. Batteux, C. Chapron, Charles Chapron, Chapron C
Journal de gynecologie, obstetrique et biologie de la reproduction · 2014 · vol. 43(9) , pp. 735–743 · doi:10.1016/j.jgyn.2014.06.014 · PMID:25063483 · W2035610199
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This paper investigated elevated serum concentrations of interleukin-1β and interleukin-1sRII in patients with deep infiltrating endometriosis.

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Abstract

ObjectivesTo assess interleukin-1β (IL-1β) and its inhibitory soluble interleukin-1 receptor type II (IL-1sRII) levels into the serum of patients with various forms of endometriosis and normal women, and investigate the correlation with disease activity.Patients and methodsIn this prospective laboratory study (2005-2010), 510 women with histologically proven endometriosis and 93 endometriosis-free controls have been enrolled. Laparoscopic complete exploration of the abdominopelvic cavity and blood samples have been performed in each patient. For each serum, IL-1β and IL-1sRII have been evaluated using Elisa.ResultsIL-1β and IL-1sRII have been respectively detectable in 64% and 54.6% of serum samples from all 603 women studied. IL-1β was higher in women with deep infiltrating endometriosis (DIE) (mean 10.0pg/mL [0.005-416.2]) than in endometriosis-free women (mean 0.5pg/mL [0.01-1.7], P<0.01) or in women with superficial endometriosis (SUP) (mean 0.6pg/mL [0.1-2.9], P<0.01). Also, IL-1sRII was higher in DIE (mean 236.7pg/mL [0.9-6975]) than in the witness group (mean 85.0pg/mL [1-235.2], P<0.05) or in SUP (mean 85.1pg/mL [0.6-302], P<0.01).ConclusionThis study highlights both a marked significant increase in serum IL-1β and IL-1sRII levels in DIE compared to SUP and normal women and suggests that a defect in the control of IL-1 can impact the pathophysiology of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Interleukin-1beta Receptors, Interleukin-1 Type II Adult Endometriosis Enzyme-Linked Immunosorbent Assay Female Humans Interleukin-1beta Prospective Studies Receptors, Interleukin-1 Type II

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