Endometriosis in the setting of Muckle-Wells syndrome treated with an IL-1β antagonist

Natsuko Sasaki-Saito, Yu Sawada, Shun Ohmori, Daisuke Omoto, Sanehito Haruyama, Manabu Yoshioka, Daisuke Nishio, Motonobu Nakamura
European journal of dermatology : EJD · 2017 · vol. 27(4) , pp. 442–443 · doi:10.1684/ejd.2017.3052 · PMID:28508753 · W2739197276
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This case report describes endometriosis in a patient with Muckle-Wells syndrome treated with an IL-1β antagonist.

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The paper describes endometriosis occurring in a patient with Muckle-Wells syndrome, a form of cryopyrin-associated autoinflammatory syndrome due to heterozygous NLRP3 (CIAS) mutations, and reports treatment with an interleukin-1β (IL-1β) antagonist. It provides a clinical narrative framed by the broader context that IL-1 antagonists are being used as therapy in autoinflammatory conditions, but it does not present a controlled study design. A key caveat is that the work is limited to a small case-based discussion rather than systematic, generalizable evidence. This paper is centrally about endometriosis—specifically endometriosis developing in the setting of Muckle-Wells syndrome and treated with an IL-1β antagonist.

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European Journal of Dermatology MENUEndometriosis in the setting of Muckle-Wells syndrome treated with an IL-1β antagonist Volume 27, numéro 4, July-August 2017 Illustrations Department of Dermatology, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan - DOI : 10.1684/ejd.2017.3052 - Page(s) : 442-3 - Année de parution : 2017 Cryopyrin-associated autoinflammatory syndrome (CIAS) is characterized by a triad of rash, arthropathy, and central nervous system involvement [1]. Chronic infantile neurological cutaneous articular syndrome (CINCA), Muckle-Wells syndrome, and familial cold autoinflammatory syndrome have been shown to be allelic, caused by heterozygous mutations in the CIAS gene, NLPR3, on chromosome 1q44, which encodes a pyrin-like protein [2]. Interleukin (IL)-1 antagonists are emerging as an effective therapy [...]

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Condition tags

endometriosis

MeSH descriptors

Cryopyrin-Associated Periodic Syndromes Cryopyrin-Associated Periodic Syndromes Endometriosis Interleukin-1beta Interleukin 1 Receptor Antagonist Protein Cryopyrin-Associated Periodic Syndromes Endometriosis Endometriosis Female Humans Interleukin-1beta Interleukin-1beta Interleukin 1 Receptor Antagonist Protein Middle Aged Mutation NLR Family, Pyrin Domain-Containing 3 Protein NLR Family, Pyrin Domain-Containing 3 Protein

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