Concentrations of interleukin (IL)-1α, IL-1 soluble receptor type II (IL-1 sRII) and IL-1 receptor antagonist (IL-1 Ra) in the peritoneal fluid and serum of infertile women with endometriosis

Zdzisława Kondera-Anasz, Zdzisława Kondera‐Anasz, Justyna Sikora, Aleksandra Mielczarek-Palacz, Aleksandra Mielczarek‐Palacz, Monika Jońca, Jońca M
European journal of obstetrics, gynecology, and reproductive biology · 2005 · vol. 123(2) , pp. 198–203 · doi:10.1016/j.ejogrb.2005.04.019 · PMID:16046047 · W2011814811
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This study measured levels of IL-1α, IL-1 sRII, and IL-1 Ra in the peritoneal fluid and serum of infertile women with endometriosis to understand their involvement.

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Abstract

ObjectiveEndometriosis is an immune system-related gynaecological disease, characterised by an increase in number and activation of peritoneal macrophages. One of macrophage-derived factors is interleukin (IL)-1. The effects of IL-1 are inhibited by IL-1 receptor type II (IL-1 RII), soluble forms of IL-1 RII (IL-1 sRII) and IL-1 receptor antagonist (IL-1 Ra). The aim of our work was to study the IL-1alpha, IL-1 sRII and IL-1 Ra levels in the peritoneal fluid (PF) and serum of women with endometriosis in relation to stage of disease.Study designConcentrations of IL-1alpha, IL-1 sRII and IL-1 Ra were measured by ELISA assay in the PF and serum of 58 women; 43 with and 15 without endometriosis (control group).ResultsElevated PF and serum IL-1alpha and IL-1 Ra levels in the women with endometriosis in comparison with the control group were observed. IL-1 sRII levels in PF and serum were higher in the controls than in the women with endometriosis. Concentrations of IL-1alpha and IL-1 sRII were higher in advanced endometriosis, but higher IL-1 Ra was observed in the early stage of the disease.ConclusionImpairment of regulation IL-1 activity in the peritoneal fluid and serum of women with endometriosis may play an important role in the pathogenesis and development of the disease.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Infertility, Female Interleukin-1 Receptors, Interleukin-1 Sialoglycoproteins Adult Ascitic Fluid Ascitic Fluid Endometriosis Endometriosis Endometriosis Enzyme-Linked Immunosorbent Assay Female Humans Infertility, Female Infertility, Female Interleukin-1 Interleukin-1 Interleukin 1 Receptor Antagonist Protein Laparoscopy

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