Cytokines and Endometriosis - the Role of Immunological Alterations

Ioana Ilie, Razvan Ilie
2013 · W2183043302
article OA: closed CC0 ⤵ 15 in-corpus citations Metadata only
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This paper reviews the role of cytokines like TNF-α, IL-1β, and IL-6 in the peritoneal fluid of endometriosis patients and their connection to inflammation and tissue repair.

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Abstract

Endometriosis is a debilitating condition, and a serious health threat to the individual patient. There has been a lot of advance in deepening its understanding since its original clinical description. There is no theory of pathogenesis that can explain all of the described manifestations of endometriosis and we still not fully understand the exact factor(s) that are responsible for the survival and subsequent implantation of the displaced endometrium.This establishment of endometriotic implants may be partly explained with the understanding of the innate or acquired properties of the endometrium and defective immune clearance. Among the several cytokines or chemokines identified in great number in the peritoneal fluid (PF) of patients with endometriosis are macrophage migration inhibitory factor, TNF-α, IL-1β, IL-6, IL-8, regulated on activation, normal T expressed and secreted (RANTES), and monocyte chemoattractant protein-1 (MCP-1). There is a tight connection between endometriosis-associated inflammatory response, tissue repair and neo- vascularization, on the one hand and the PF macrophages and their secretory products (cytokines), on the other. Further research is needed, however, to clarify whether observed cytokine profiles are a cause or a consequence of endometriosis.

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endometriosis

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