Decreased concentrations of soluble interleukin-1 receptor accessory protein levels in the peritoneal fluid of women with endometriosis

Michaud N, Nadège Michaud, Mahéra Al-Akoum, Al-Akoum M, Geneviève Gagnon, Gagnon G, Karine Girard, Girard K, Pierre Blanchet, Pierre J. Blanchet, Blanchet P, Rousseau JA, Julie Anne Rousseau, Julie Rousseau, Ali Akoum, Akoum A
Journal of Reproductive Immunology · 2011 · vol. 92(1-2) , pp. 68–73 · doi:10.1016/j.jri.2011.08.001 · PMID:21958553 · W2000444453
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This study found lower levels of soluble interleukin-1 receptor accessory protein in the peritoneal fluid of women diagnosed with endometriosis.

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Abstract

Interleukin 1 (IL1) may play an important role in endometriosis-associated pelvic inflammation, and natural specific inhibitors, including soluble IL1 receptor accessory protein (sIL1RAcP) and soluble IL1 receptor type 2 (sIL1R2), are critical for counterbalancing the pleiotropic effects of IL1. The objective of this study was to evaluate the levels of sIL1RAcP, together with those of sIL1R2 and IL1β, in the peritoneal fluid of women with and without endometriosis. Peritoneal fluid samples were obtained at laparoscopy and assessed by ELISA. sIL1RAcP concentrations were reduced in endometriosis stages I-II and III-IV. sIL1R2 concentrations were decreased, and those of IL1β were significantly increased in endometriosis stages I-II. sIL1RAcP and sIL1R2 concentrations were significantly decreased in the secretory phase of the menstrual cycle, and IL1β concentrations were elevated in the proliferative and the secretory phases. sIL1RAcP and sIL1R2 concentrations were reduced in women with endometriosis who were infertile, fertile, suffering from pelvic pain or pain-free. However, IL1β concentrations were significantly reduced in women with endometriosis who were infertile or had pelvic pain. These changes may exacerbate the local peritoneal inflammatory reaction observed in women with endometriosis and contribute to endometriosis pathophysiology and the major symptoms of this disease.

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Condition tags

endometriosischronic_pelvic_pain

MeSH descriptors

Ascitic Fluid Endometriosis Interleukin-1beta Interleukin-1 Receptor Accessory Protein Receptors, Interleukin-1 Type II Adult Ascitic Fluid Disease Progression Endometriosis Endometriosis Female Gene Expression Regulation Gene Expression Regulation Humans Infertility Inflammation Interleukin-1beta Interleukin-1beta Interleukin-1beta Interleukin-1 Receptor Accessory Protein

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