Pengaruh Ekstrak Kulit Buah Naga Merah (Hylocereus Polyrhizus) Terhadap Kadar Interleukin-6 Mencit Model Endometriosis

Sagita Candra Puspitasari
In: Jurnal Biosains Pascasarjana · 2018 · vol. 19(3) , pp. 197 · doi:10.20473/jbp.v19i3.2017.197-210 · W2772940692
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Red dragon fruit peel extract significantly reduced Interleukin-6 levels in a mouse model of endometriosis.

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This true experimental study evaluated the effect of red dragon fruit peel extract (Hylocereus polyrhizus) on interleukin-6 levels in 30 female mice using an endometriosis model. Mice were induced with endometriosis for 14 days, then separated into five groups and either received Na-CMC 0.5% (negative/positive controls) or received tiered doses of the extract for a further 14 days; outcomes were assessed with a randomized post-test only control group design. IL-6 concentrations differed significantly among groups, and extract administration reduced IL-6 with statistical significance (p<0.05). The study does not report measures of extract characterization, toxicity, or the baseline comparability of IL-6 across groups, limiting interpretation of dose-response and mechanism beyond IL-6 modulation. This paper is centrally about endometriosis — it tests whether red dragon fruit peel extract lowers IL-6 in a mouse model of endometriosis.

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Abstract

ABSTRAK Pada endometriosis terjadi proses inflamasi lokal pada pelvis dengan perubahan fungsi sel-sel imun di lingkungan peritoneum. Respon imun pada zalir peritoneum endometriosis berupa peningkatan aktivitas makrofag dan terjadinya sekresi berlebihan beberapa sikotin seperti IL-1, IL-6, IL-8, dan TNF-⍺ sehingga menyebabkan aktivasi faktor transkripsi NF-KB. Buah naga merah merupakan salah satu tanaman yang mampu menghambat sekresi sitotin NF-κB dari endometriosis. Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak buah naga merah terhadap kadar Interleukin-6 mencit model endometriosis. Sampel 30 mencit betina dibagi menjadi 5 kelompok yang terdiri dari kelompok kontrol positif, kelompok kontrol negatif dan kelompok perlakuan dosis bertingkat. Kontrol positif dan kelompok perlakuan dijadikan endometriosis selama 14 hari, kemudian 14 hari berikutnya kelompok positif dan kelompok negatif diberi larutan Na-CMC 0,5%, sedangkan kelompok perlakuan diberi dosis bertingkat. Jenis penelitian ini true eksperimental dengan menggunakan rancangan randomized post test only control group design. Hasil penelitian ini menunjukkan bahwa terdapat perbedaan yang signifikan pada kadar Interleukin-6 antar kelompok. Pemberian ekstrak kulit buah naga pada mencit model endometriosis dapat menekan kadar Interleukin-6 dengan hasil signifikan p<0,05. Kata kunci : ekstrak kulit buah hylocereus polyrhizus, endometriosis, IL-6,
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Pengaruh Ekstrak Kulit Buah Naga Merah (Hylocereus Polyrhizus) Terhadap Kadar Interleukin-6 Mencit Model Endometriosis Downloads ABSTRAK Pada endometriosis terjadi proses inflamasi lokal pada pelvis dengan perubahan fungsi sel-sel imun di lingkungan peritoneum. Respon imun pada zalir peritoneum endometriosis berupa peningkatan aktivitas makrofag dan terjadinya sekresi berlebihan beberapa sikotin seperti IL-1, IL-6, IL-8, dan TNF-⺠sehingga menyebabkan aktivasi faktor transkripsi NF-KB. Buah naga merah merupakan salah satu tanaman yang mampu menghambat sekresi sitotin NF-κB dari endometriosis. Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak buah naga merah terhadapkadar Interleukin-6 mencit model endometriosis.Sampel 30mencit betina dibagi menjadi 5kelompok yang terdiri dari kelompok kontrol positif, kelompok kontrol negatif dan kelompok perlakuan dosis bertingkat. Kontrol positif dan kelompok perlakuan dijadikan endometriosis selama 14 hari, kemudian 14 hari berikutnya kelompok positif dan kelompok negatif diberi larutan Na-CMC 0,5%, sedangkan kelompok perlakuan diberi dosis bertingkat. Jenis penelitian ini true eksperimental dengan menggunakan rancangan randomized post test only control group design. Hasil penelitian ini menunjukkan bahwa terdapat perbedaan yang signifikan pada kadar Interleukin-6 antar kelompok. Pemberian ekstrak kulit buah naga pada mencit model endometriosis dapat menekan kadar Interleukin-6 dengan hasil signifikan p<0,05. Kata kunci : ekstrak kulit buah hylocereus polyrhizus, endometriosis, IL-6, DAFTAR PUSTAKA Annas, JY., Hendarto, H., Widjiati. 2014. Khasiat Berbagai Dosis Suplementasi Kurkumin pada Progresivitas Endometriosis di Hewan Coba Mencit. Majalah Obstetri dan Ginekologi. 22 (3) : 118-125. ASRM, Practice. Committee. 2012. Endometriosis and infertility: a committee opinion. 98 : 591-8 Fertility Sterility. 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Genistein suppresses tuor necrosis factor a induced inflammation via modulating reactive oxygen species/Akt/nuclear factorNF-KB and adenosine monophosphate activated ptotein kinase signal pathways in human synoviocyte MH7 a cell. 8 : 315-323. Jobin, C., Bradham, CA., Russo, MP., Juma, B., Narula, AS., Brenner, DA., and Sartor, RB. 1999. Curcumin blocks cytokine-mediated NF-KB activation and proinflammatory gene expression by inhibiting inhibitory factor I-kB kinase activity. The Journal of Immunology.163 (6) : 3474-3483. Kalimuthu, S. and Se-Kwon, K. 2013. Cell survival and apoptosis signaling the United States therapeutic target for cancer : Marine bioactive compounds. International Journal of Molecular Sciences 14 : 2334-2354. Kim, Y.S., Ahn, Y., Hong, M.H., Joo, S.Y., Kim, K.H., Sohn, I.S., Park, H.W. 2006. Curcumin attenuates Nuclear Factor-k. The Korean Society of circulation. 36 : 482-489. Liie, I., and liie, R. 2013. Cytokines and Endometriosis the Role of Immunological Alterations. Biotechnology Molecular Biology and Nanomedicine. 1(2). Martinez, RM., Longhi-Balbinot, DT., Zarpelon, AC., Staurengo-Ferrari, L., Baracat, MM., Georgetti, SR., Sassonia, RC., Verri, WA., Casagrande, R. 2014. Anti-inflammatory Activity of Betalain-Rich Dye of Beta vulgaris: Effect on Edema, Leucocyte Recruitment, Superoxide Anion, and Cytokine Production. Archives of Pharmacal Research. 38 : 494-504. May, K., Condult-Hulbert, S., Villiar, J., Kirtley, S., Kennedy, S., Becker, C. 2010. Peripheral Biomarkers of endometriosis : A systemic Review. Hum Reprod Update. 16 (6): 651-6745. Nugrahaini and Azizah. 2015. Uji Efektifitas Ekstrak Etanol Hylocereus polyrhizus Dengan Metode Geliat Pada Mencit Jantan Galur Swiss Webster. The Muhammadiyah University. Surakarta. Nurliyana, SZ., Suleiman, IMK., Aisyah, MR., Rahim, KR. 2010. Antioxydant Study Of Pulp And Peels Of Dragon Fruits : A Comparative Study. 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