Association between Interleukin-8 -251T/A Polymorphism and Endometriosis in Iranian Women

Farnoosh Rabbanizadeh, Leila Kohan, Fatemesadat Najib
In: Research in Molecular Medicine, Vol 3, Iss 2, Pp 45-49 (2015) · 2015 · W2302513318
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This study found no association between the IL-8 -251T/A polymorphism and endometriosis risk or severity in Iranian women.

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This Iranian case-control study examined whether the IL-8 -251T/A gene polymorphism is associated with endometriosis risk, genotyping 100 endometriosis patients and 100 healthy controls using PCR-RFLP and estimating odds ratios with 95% confidence intervals. The authors report no statistically significant association between IL-8 -251 variants and endometriosis development (χ2=1.02, P=0.63). Subgroup analyses by disease severity also found no significant relationship between the polymorphism and either risk or severity (P>0.05). This paper is centrally about endometriosis — it tests the association between the IL-8 -251T/A polymorphism and endometriosis risk in Iranian women.

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Abstract

Bachground: Endometriosis is a disease of female genital system, which is defined by the presence of ectopic endometrial tissue outside the uterine cavity. IL-8 is an autocrine growth factor in the endometrium that contributes to the pathogenesis of endometriosis. The aim of this study was to investigate the association between -251T/A polymorphism in the IL-8 gene and endometriosis risk in Iranian population. Materials and Methods: This case-control study was performed on 100 endometriosis patients and 100 healthy individuals. The IL-8 -251T/A genotypes were determined using PCR-RFLP method. The association between genotypes of the -251T/A polymorphism and the endometriosis risk was examined by use of odds ratios (OR) and 95% of confidence intervals (CIs). Results: No statistically significant associations were observed between IL-8 -251 variants and the risk of endometriosis development (&chi2: 1.02, P: 0.63). In addition, subgroup analysis according to severity of disease, were unable to identify any association between IL-8 -251T/A polymorphism and endometriosis (P>0.05), and there was no significant association between IL-8 -251T/A and the severity of endometriosis. Conclusions: This is the first study regard to association of -251T/A polymorphism with endometriosis risk. Our results indicate that the presence of the -251T/A polymorphism in IL-8 gene is not associated with the risk of endometriosis.
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Research in Molecular Medicine (Apr 2015) Association between Interleukin-8 -251T/A Polymorphism and Endometriosis in Iranian Women Abstract Bachground: Endometriosis is a disease of female genital system, which is defined by the presence of ectopic endometrial tissue outside the uterine cavity. IL-8 is an autocrine growth factor in the endometrium that contributes to the pathogenesis of endometriosis. The aim of this study was to investigate the association between -251T/A polymorphism in the IL-8 gene and endometriosis risk in Iranian population. Materials and Methods: This case-control study was performed on 100 endometriosis patients and 100 healthy individuals. The IL-8 -251T/A genotypes were determined using PCR-RFLP method. The association between genotypes of the -251T/A polymorphism and the endometriosis risk was examined by use of odds ratios (OR) and 95% of confidence intervals (CIs). Results: No statistically significant associations were observed between IL-8 -251 variants and the risk of endometriosis development (&chi2: 1.02, P: 0.63). In addition, subgroup analysis according to severity of disease, were unable to identify any association between IL-8 -251T/A polymorphism and endometriosis (P>0.05), and there was no significant association between IL-8 -251T/A and the severity of endometriosis. Conclusions: This is the first study regard to association of -251T/A polymorphism with endometriosis risk. Our results indicate that the presence of the -251T/A polymorphism in IL-8 gene is not associated with the risk of endometriosis.

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