Peritoneal fluid concentrations of interleukin-8 in patients with endometriosis depend on the severity of the disorder and are higher in the luteal phase

Carlos Calhaz–Jorge, C Calhaz-Jorge, A P Costa, M C Santos, M L Palma-Carlos
Human Reproduction · 2003 · vol. 18(3) , pp. 593–597 · doi:10.1093/humrep/deg122 · PMID:12615831 · W2097680011
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Peritoneal fluid interleukin-8 concentrations are higher in patients with moderate/severe endometriosis and during the luteal phase, with red lesions associated with increased levels in the luteal phase.

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Abstract

BACKGROUND: Previous evaluations of the relationship between the concentrations of interleukin-8 (IL-8) in the peritoneal fluid and endometriosis led to non-consistent results. Our purpose was to investigate the correlation of the concentrations of IL-8 in the peritoneal fluid with the stage of endometriosis, the presence of red lesions and the phase of the menstrual cycle. METHODS: Ninety-two patients with infertility (n = 87) or undergoing sterilization (n = 5) had peritoneal fluid samples collected at laparoscopy. IL-8 determinations were performed using an enzyme-linked immunosorbent assay. RESULTS: The concentrations of IL-8 in the peritoneal fluid of the 68 women with endometriosis were not significantly different from those of the 24 controls. Patients with moderate/severe stages had IL-8 significantly higher than controls (P = 0.008) and marginally higher than patients with minimal/mild endometriosis (P = 0.053). Concentrations of IL-8 were significantly higher in patients than in controls in the luteal phase. Red lesions were associated with significantly increased levels of peritoneal fluid IL-8 only in the luteal phase. CONCLUSIONS: Our findings reinforce the importance of IL-8 in the pathogenesis of endometriosis.

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Ascitic Fluid Endometriosis Interleukin-8 Luteal Phase Adult Ascitic Fluid Case-Control Studies Endometriosis Endometriosis Endometriosis Endometriosis Enzyme-Linked Immunosorbent Assay Female Humans Infertility, Female Infertility, Female Interleukin-8 Luteal Phase Osmolar Concentration Severity of Illness Index

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Cited by (38)

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