Eutopic and ectopic stromal cells from patients with endometriosis exhibit differential invasive, adhesive, and proliferative behavior

Delbandi AA, Ali-Akbar Delbandi, Ali‐Akbar Delbandi, Mahmoud Mahmoudi, Mahmoudi M, Shervin A, Adel Shervin, Elham Akbari, Akbari E, Mahmood Jeddi-Tehrani, Mahmood Jeddi‐Tehrani, Sankian M, Mojtaba Sankian, Kazemnejad S, Somayeh Kazemnejad, Zarnani AH, Amir-Hassan Zarnani, Amir‐Hassan Zarnani
Fertility and sterility · 2013 · vol. 100(3) , pp. 761–769 · doi:10.1016/j.fertnstert.2013.04.041 · PMID:23721717 · W2062900332
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Endometriosis stromal cells from eutopic and ectopic sites displayed distinct invasive, adhesive, and proliferative behaviors.

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Abstract

ObjectiveTo study immunophenotype, differential proliferation capacity, invasiveness, adhesion, and cytokine production in ectopic and eutopic endometrial stromal cells (EESCs and EuESCs) from patients with endometriosis.DesignIn vitro study.SettingAcademic research center.Patient(s)Patients with ovarian endometriosis (endometrioma) and nonendometriotic controls.Intervention(s)None.Main outcome measure(s)EESCs and EuESCs from 25 patients with endometrioma and ESCs from 20 nonendometriotic controls (CESCs) were isolated, and their immunophenotype, proliferation, invasion, adhesion, and cytokine production were assessed and compared.Result(s)Isolated ESCs from all three sources expressed markers specific for cells of mesenchymal origin but were negative for hematopoietic markers. EESCs exhibited a significantly lower proliferation rate in fibronectin-coated plates and less invasive capacity compared with CESCs or EuESCs. Among all stromal cell groups studied, EuESCs showed the highest invasive behavior. EESCs adhered more firmly to extracellular matrix than EuESCs or CESCs in all time intervals examined. The levels of interleukin (IL) -6 and IL-8 production by EESCs were significantly higher compared with those of EuESCs or CESCs.Conclusion(s)The results of the present study demonstrated that retrograde menstruation alone does not account for the pathogenesis of endometriosis as eutopic and ectopic counterparts of ESCs from patients with endometriosis exhibit differential invasive, adhesive, and proliferative behavior.

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Condition tags

endometriosis

MeSH descriptors

Cell Movement Cell Proliferation Choristoma Endometriosis Stromal Cells Adult Cell Adhesion Cells, Cultured Choristoma Cytokines Cytokines Endometriosis Endometrium Female Humans Middle Aged Stromal Cells Young Adult

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