Telocytes and endometriosis

Endometriosis involving the presence and growth of glands and stroma outside the uterine cavity is a common, inflammatory, benign gynecologic disease. Nevertheless, no single theory can exactly account for the pathogenesis of endometriosis. Telocytes, a kind of novel mesenchymal cells, have been suggested to be crucial in promoting angiogenesis and increasing the activity of endometrial interstitial cells and inflammatory cells. Given above roles, telocytes may be considered as the possible pathogenesis of endometriosis. We reviewed the current literature on telocytes. The following aspects were considered: (A) the telocytes’ typical characteristics, function, and morphological changes in endometriosis; (B) the potential role of telocytes in endometriosis by impacting the inflammation, invasion, and angiogenesis; (C) telocytes as the potential treatment options for endometriosis. Similar content being viewed by others

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ZLZ: manuscript reviewing, editing, and approving. Corresponding author Ethics declarations Conflict of interest The authors declare no conflict of interest. Ethical approval The study was approved by the Ethic Committee of Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China. It was performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. Informed consent Informed consent was obtained from all individual participants included in the study. Additional information Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Rights and permissions About this article Cite this article Xu, T., Zhang, H. & Zhu, Z. Telocytes and endometriosis. Arch Gynecol Obstet 307, 39–49 (2023). https://doi.org/10.1007/s00404-022-06634-w Received: Accepted: Published: Version of record: Issue date: DOI: https://doi.org/10.1007/s00404-022-06634-w