Exosomes and their cargo are important regulators of cell function in endometriosis

Shay Freger; Shay M. Freger; Mathew Leonardi; Lauren Foster; Warren George Foster

doi:10.1016/j.rbmo.2021.05.022

Exosomes and their cargo are important regulators of cell function in endometriosis

Shay Freger, Shay M. Freger, Mathew Leonardi, Lauren Foster, Warren George Foster

Reproductive biomedicine online · 2021 · vol. 43(3) , pp. 370–378 · doi:10.1016/j.rbmo.2021.05.022 · PMID:34272164 · W3170191620

review OA: bronze CC0 ⤵ 18 in-corpus citations

🔓 Open OA copy View on OpenAlex View on PubMed View at publisher

⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This review examines exosomes and their molecular cargo as key regulators of cellular function within the context of endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

My notes (saved in your browser only)

Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometrium Exosomes Peritoneal Diseases Endometriosis Endometriosis Endometriosis Endometriosis Endometrium Endometrium Epithelial Cells Epithelial Cells Exosomes Exosomes Female Humans Immune System Immune System MicroRNAs MicroRNAs

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (85)

Aberrant integrin expression in the endometrium of women with endometriosis via openalex
Aberrant integrin expression in the endometrium of women with endometriosis. via openalex
Alteration of Myeloid-Derived Suppressor Cells, Chronic Inflammatory Cytokines, and Exosomal miRNA Contribute to the Peritoneal Immune Disorder of Patients With Endometriosis via openalex
Analysis of Exosomal lncRNA, miRNA and mRNA Expression Profiles and ceRNA Network Construction in Endometriosis via openalex
Angiogenesis lymphangiogenesis and neurogenesis in endometriosis via openalex
Aromatase in endometriosis and uterine leiomyomata via openalex
Characterization of exosomes in peritoneal fluid of endometriosis patients via openalex
Differential Levels of Regulatory T Cells and T-Helper-17 Cells in Women With Early and Advanced Endometriosis via openalex
DNA methylation of HOXA10 in eutopic and ectopic endometrium via openalex
Endometriosis-Associated Macrophages: Origin, Phenotype, and Function via openalex
Eutopic and ectopic stromal cells from patients with endometriosis exhibit differential invasive, adhesive, and proliferative behavior via openalex
Eutopic endometrium from patients with endometriosis modulates the expression of CD36 and SIRP‐α in peritoneal macrophages via openalex
Eutopic stromal cells of endometriosis promote neuroangiogenesis via exosome pathway† via openalex
Evaluation of apoptosis and angiogenesis in ectopic and eutopic stromal cells of patients with endometriosis compared to non-endometriotic controls via openalex
Evaluation of M1 and M2 macrophages in ovarian endometriomas from women affected by endometriosis at different stages of the disease via openalex
Exacerbation of Endometriosis Due To Regulatory T-Cell Dysfunction via openalex
Exosomes derived from endometriotic stromal cells have enhanced angiogenic effects in vitro via openalex
Extracellular vesicle-mediated transfer of the lncRNA-TC0101441 promotes endometriosis migration/invasion via openalex
Extracellular vesicles from endometriosis patients are characterized by a unique miRNA-lncRNA signature via openalex
Immune-inflammation gene signatures in endometriosis patients via openalex
Krüppel-Like Factor 9 Deficiency in Uterine Endometrial Cells Promotes Ectopic Lesion Establishment Associated With Activated Notch and Hedgehog Signaling in a Mouse Model of Endometriosis via openalex
Macrophage‐derived insulin‐like growth factor‐1 is a key neurotrophic and nerve‐sensitizing factor in pain associated with endometriosis via openalex
Macrophages alternatively activated by endometriosis-exosomes contribute to the development of lesions in mice via openalex
Macrophages display proinflammatory phenotypes in the eutopic endometrium of women with endometriosis with relevance to an infectious etiology of the disease via openalex
MicroRNA expression profile in endometriosis: its relation to angiogenesis and fibrinolytic factors via openalex
MiR-199a inhibits the angiogenic potential of endometrial stromal cells under hypoxia by targeting HIF-1α/VEGF pathway. via openalex
Neutrophil recruitment and function in endometriosis patients and a syngeneic murine model via openalex
Peripheral biomarkers of endometriosis: a systematic review via openalex
Protein Inhibitor of Activated STAT3 (PIAS3) Is Down-Regulated in Eutopic Endometrium of Women with Endometriosis via openalex
Relationship between the magnetic resonance imaging appearance of adenomyosis and endometriosis phenotypes via openalex
<scp>miRNA</scp> ‐199a‐5p regulates <scp>VEGFA</scp> in endometrial mesenchymal stem cells and contributes to the pathogenesis of endometriosis via openalex
Serum Exosomal MicroRNAs as Potential Circulating Biomarkers for Endometriosis via openalex
The crosstalk between endometrial stromal cells and macrophages impairs cytotoxicity of NK cells in endometriosis by secreting IL-10 and TGF-β via openalex
The dynamic changes in the number of uterine natural killer cells are specific to the eutopic but not to the ectopic endometrium in women and in a baboon model of endometriosis via openalex
The endometrial immune environment of women with endometriosis via openalex
The Exosomal Long Noncoding RNA aHIF is Upregulated in Serum From Patients With Endometriosis and Promotes Angiogenesis in Endometriosis via openalex
The Pathogenesis of Endometriosis: Molecular and Cell Biology Insights via openalex
Update on Biomarkers for the Detection of Endometriosis via openalex
Vascular endothelial growth factor (VEGF) and ovarian endometriosis: correlation between VEGF serum levels, VEGF cellular expression, and pelvic pain via openalex
W2148896940 via openalex
W2511990668 via openalex
W2589694509 via openalex
W2147854273 via openalex
W2754791272 via openalex
W2763367588 via openalex
W2790656413 via openalex
W2131678991 via openalex
W2897141896 via openalex
W2129062330 via openalex
W2900756811 via openalex
W2125052189 via openalex
W2912004675 via openalex
W2914782620 via openalex
W2119812304 via openalex
W2925372744 via openalex
W2925579059 via openalex
W2072167135 via openalex
W2064911524 via openalex
W2966521813 via openalex
W2040041663 via openalex
W2975609864 via openalex
W2978059917 via openalex
W2978951376 via openalex
W2035844407 via openalex
W2991792334 via openalex
W2004388967 via openalex
W1980593265 via openalex
W1974954833 via openalex
W1964653452 via openalex
W3011224082 via openalex
W1839188703 via openalex
W4234160457 via openalex
W1500925570 via openalex
W6625714467 via openalex
W6645299560 via openalex
W2228844665 via openalex
W6775462142 via openalex
W2235604943 via openalex
W2212865794 via openalex
W2270829764 via openalex
W2274491511 via openalex
W2276360944 via openalex
W2176301470 via openalex
W2170852633 via openalex
W2468996569 via openalex

Cited by (18)

Source provenance

europepmc: last seen: 2026-06-04T01:30:01.192114+00:00
openalex: last seen: 2026-06-10T17:14:06.276822+00:00
pubmed: last seen: 2026-05-13T22:24:31.988741+00:00

License: CC0 · commercial use OK

[1] Aberrant integrin expression in the endometrium of women with endometriosis via openalex

[2] Aberrant integrin expression in the endometrium of women with endometriosis. via openalex

[3] Alteration of Myeloid-Derived Suppressor Cells, Chronic Inflammatory Cytokines, and Exosomal miRNA Contribute to the Peritoneal Immune Disorder of Patients With Endometriosis via openalex

[4] Analysis of Exosomal lncRNA, miRNA and mRNA Expression Profiles and ceRNA Network Construction in Endometriosis via openalex

[5] Angiogenesis lymphangiogenesis and neurogenesis in endometriosis via openalex

[6] Aromatase in endometriosis and uterine leiomyomata via openalex

[7] Characterization of exosomes in peritoneal fluid of endometriosis patients via openalex

[8] Differential Levels of Regulatory T Cells and T-Helper-17 Cells in Women With Early and Advanced Endometriosis via openalex

[9] DNA methylation of HOXA10 in eutopic and ectopic endometrium via openalex

[10] Endometriosis-Associated Macrophages: Origin, Phenotype, and Function via openalex

[11] Eutopic and ectopic stromal cells from patients with endometriosis exhibit differential invasive, adhesive, and proliferative behavior via openalex

[12] Eutopic endometrium from patients with endometriosis modulates the expression of CD36 and SIRP‐α in peritoneal macrophages via openalex

[13] Eutopic stromal cells of endometriosis promote neuroangiogenesis via exosome pathway† via openalex

[14] Evaluation of apoptosis and angiogenesis in ectopic and eutopic stromal cells of patients with endometriosis compared to non-endometriotic controls via openalex

[15] Evaluation of M1 and M2 macrophages in ovarian endometriomas from women affected by endometriosis at different stages of the disease via openalex

[16] Exacerbation of Endometriosis Due To Regulatory T-Cell Dysfunction via openalex

[17] Exosomes derived from endometriotic stromal cells have enhanced angiogenic effects in vitro via openalex

[18] Extracellular vesicle-mediated transfer of the lncRNA-TC0101441 promotes endometriosis migration/invasion via openalex

[19] Extracellular vesicles from endometriosis patients are characterized by a unique miRNA-lncRNA signature via openalex

[20] Immune-inflammation gene signatures in endometriosis patients via openalex

[21] Krüppel-Like Factor 9 Deficiency in Uterine Endometrial Cells Promotes Ectopic Lesion Establishment Associated With Activated Notch and Hedgehog Signaling in a Mouse Model of Endometriosis via openalex

[22] Macrophage‐derived insulin‐like growth factor‐1 is a key neurotrophic and nerve‐sensitizing factor in pain associated with endometriosis via openalex

[23] Macrophages alternatively activated by endometriosis-exosomes contribute to the development of lesions in mice via openalex

[24] Macrophages display proinflammatory phenotypes in the eutopic endometrium of women with endometriosis with relevance to an infectious etiology of the disease via openalex

[25] MicroRNA expression profile in endometriosis: its relation to angiogenesis and fibrinolytic factors via openalex

[26] MiR-199a inhibits the angiogenic potential of endometrial stromal cells under hypoxia by targeting HIF-1α/VEGF pathway. via openalex

[27] Neutrophil recruitment and function in endometriosis patients and a syngeneic murine model via openalex

[28] Peripheral biomarkers of endometriosis: a systematic review via openalex

[29] Protein Inhibitor of Activated STAT3 (PIAS3) Is Down-Regulated in Eutopic Endometrium of Women with Endometriosis via openalex

[30] Relationship between the magnetic resonance imaging appearance of adenomyosis and endometriosis phenotypes via openalex

[31] <scp>miRNA</scp> ‐199a‐5p regulates <scp>VEGFA</scp> in endometrial mesenchymal stem cells and contributes to the pathogenesis of endometriosis via openalex

[32] Serum Exosomal MicroRNAs as Potential Circulating Biomarkers for Endometriosis via openalex

[33] The crosstalk between endometrial stromal cells and macrophages impairs cytotoxicity of NK cells in endometriosis by secreting IL-10 and TGF-β via openalex

[34] The dynamic changes in the number of uterine natural killer cells are specific to the eutopic but not to the ectopic endometrium in women and in a baboon model of endometriosis via openalex

[35] The endometrial immune environment of women with endometriosis via openalex

[36] The Exosomal Long Noncoding RNA aHIF is Upregulated in Serum From Patients With Endometriosis and Promotes Angiogenesis in Endometriosis via openalex

[37] The Pathogenesis of Endometriosis: Molecular and Cell Biology Insights via openalex

[38] Update on Biomarkers for the Detection of Endometriosis via openalex

[39] Vascular endothelial growth factor (VEGF) and ovarian endometriosis: correlation between VEGF serum levels, VEGF cellular expression, and pelvic pain via openalex

[40] W2148896940 via openalex

[41] W2511990668 via openalex

[42] W2589694509 via openalex

[43] W2147854273 via openalex

[44] W2754791272 via openalex

[45] W2763367588 via openalex

[46] W2790656413 via openalex

[47] W2131678991 via openalex

[48] W2897141896 via openalex

[49] W2129062330 via openalex

[50] W2900756811 via openalex

[51] W2125052189 via openalex

[52] W2912004675 via openalex

[53] W2914782620 via openalex

[54] W2119812304 via openalex

[55] W2925372744 via openalex

[56] W2925579059 via openalex

[57] W2072167135 via openalex

[58] W2064911524 via openalex

[59] W2966521813 via openalex

[60] W2040041663 via openalex

[61] W2975609864 via openalex

[62] W2978059917 via openalex

[63] W2978951376 via openalex

[64] W2035844407 via openalex

[65] W2991792334 via openalex

[66] W2004388967 via openalex

[67] W1980593265 via openalex

[68] W1974954833 via openalex

[69] W1964653452 via openalex

[70] W3011224082 via openalex

[71] W1839188703 via openalex

[72] W4234160457 via openalex

[73] W1500925570 via openalex

[74] W6625714467 via openalex

[75] W6645299560 via openalex

[76] W2228844665 via openalex

[77] W6775462142 via openalex

[78] W2235604943 via openalex

[79] W2212865794 via openalex

[80] W2270829764 via openalex

[81] W2274491511 via openalex

[82] W2276360944 via openalex

[83] W2176301470 via openalex

[84] W2170852633 via openalex

[85] W2468996569 via openalex