Effect of ovarian involvement on peritoneal fl uid cytokine concentrations in endometriosis
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Abstract
Peritoneal fl uid cytokines are important for initiation and progression of endometriosis. The objective of this study was to compare a group of fi ve cytokines (interleukins IL-1β, IL-6, IL-8, IL-13 and tumour necrosis factor α; TNFα) in peritoneal fl uid of endometriosis patients with ovarian involvement (Group I, n = 17) to those in patients without ovarian involvement (Group II, n = 33) and to a reference group without endometriosis (Group III, n = 25). All three groups were comparable regarding age, parity and body mass index. IL-8 concentrations were signifi cantly higher in groups I and II compared with the reference group (P = 0.01 and 0.02, respectively). Similarly, TNFα concentrations were signifi cantly higher in groups I and II compared with the reference group (P < 0.0001 and 0.0004, respectively). All other cytokines were comparable in the three groups. No signifi cant differences were found between groups I and II with respect to the cytokines measured. In conclusion, peritoneal fl uid IL-8 and TNFα concentrations are signifi cantly higher in endometriosis. Ovarian involvement does not alter the pattern of cytokines. It appears that the infl ammatory mediators of endometriosis are similar with and without ovarian involvement.
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- last seen: 2026-06-04T00:00:01.174412+00:00
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