Local peritoneal factors: Their role in infertility associated with endometriosis
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This paper investigates the impact of local factors within the peritoneal cavity on infertility linked to endometriosis.
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Abstract
In order to detect peritoneal abnormalities that could account for infertility associated with endometriosis, 122 infertile individuals were studied at the time of laparoscopy for diagnostic purposes or for in vitro fertilization. Four groups were defined: group 1, laparoscopy without endometriosis; group 2, laparoscopy with endometriosis; group 3, in vitro fertilization without endometriosis; and group 4, in vitro fertilization with endometriosis. Mean peritoneal fluid volume was greater, although not significantly so, in group 4 (29.0 +/- 6.6 ml, mean +/- SEM) than in group 3 (18.2 +/- 2 ml). The concentration and total number of pelvic macrophages were similar for groups 1 and 2. The total number of pelvic macrophages was increased in group 4 (16.9 +/- 4.2 x 10(6)) versus group 3 (10.0 +/- 1.8 x 10(6)) (p = 0.08). The mean sperm phagocytosis in vitro did not differ among the four groups studied. Interleukin 1 activity within the peritoneal fluid and the in vitro interleukin 1 production rate did not differ between individuals with and without endometriosis. Peritoneal fluid and macrophage supernatants from individuals with endometriosis were not embryotoxic when studied in an in vitro mouse embryo system.
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Cited by (49)
- Fas-Related Apoptosis of Peritoneal Fluid Macrophages in Endometriosis Patients: Understanding the Disease 2017
- Endometriosis and infertility: cause or consequence? 2009
- Pyruvate reduces in vitro the embryotoxic effect of peritoneal fluid from infertile women with endometriosis 2008
- L-carnitine supplementation reduces oocyte cytoskeleton damage and embryo apoptosis induced by incubation in peritoneal fluid from patients with endometriosis 2008
- Effect of ovarian involvement on peritoneal fl uid cytokine concentrations in endometriosis 2007
- Infertilidad y endometriosis 2007
- Effects of peritoneal fluid on preimplantation mouse embryo development and apoptosis in vitro 2005
- Increase of Activated Mast Cells in Human Endometriosis 2005
- Endometriosis and Inflammation in Infertility 2004
- Endometriosis and Inflammation in Infertility 2004
- Immunology and Endometriosis 2003
- Peritoneal fluid environment in endometriosis. Clinicopathological implications. 2003
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- Peritoneal fluid environment in endometriosis 2003
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- Role of cytokines in endometriosis 2001
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- Role of cytokines in endometriosis 2001
- Induction of an angiogenic phenotype in endometriotic stromal cell cultures by interleukin-1 2000
- Tumour necrosis factor α concentrations in the peritoneal fluid of infertile women with minimal or mild endometriosis are lower in patients with red lesions only than in patients without red lesions 2000
- Pathophysiology of Endometriosis-Associated Infertility 1999
- The relevance of the peritoneal fluid in endometriosis-associated infertility 1999
- Current Concepts in the Pathogenesis of Endometriosis 1999
- Immunology of endometriosis 1999
- Growth factors and cytokines in the reproductive tract of women 1997
- Importance portance of reactive oxygen species in the peritoneal fluid of women with endometriosis or idiopathic infertility 1997
- PATHOPHYSIOLOGY 1997
- Correlation of Basal Menses CA‐125 Levels and 6 Month Pregnancy Rates in Women Undergoing Treatments for Infertility Without Assisted Reproductive Methods 1997
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- Spontaneous and induced synthesis of cytokines by peripheral blood monocytes in patients with endometriosis 1996
- IL‐1β TNF‐α, and IL‐2 in Peritoneal Fluid and Macrophage‐Conditioned Media of Women With Endometriosis 1995
- IL‐1β TNF‐α, and IL‐2 in Peritoneal Fluid and Macrophage‐Conditioned Media of Women With Endometriosis 1995
- Evaluation of serum-associated embryotoxicity in women with reproductive disorders 1995
- The insulin-like growth factor system in human peritoneal fluid: its effects on endometrial stromal cells and its potential relevance to endometriosis. 1994
- Endometriosis: Immune Cells and Their Products 1994
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- Peritoneal Fluid lnterleukin‐1β and Tumor Necrosis Factor in Patients With Benign Gynecologic Disease 1991
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- Endometriosis and infertility 1990
- Lymphocyte activity in the presence of peritoneal fluid from fertile women and infertile women with and without endometriosis 1989
- Reduction of the intraperitoneal inflammation associated with endometriosis by treatment with medroxyprogesterone acetate 1988
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