Endometriosis and Inflammation in Infertility

Gülden Halis, Halis G, Arici A, Aydin Arici, Aydın Arıcı
Annals of the New York Academy of Sciences · 2004 · vol. 1034(1) , pp. 300–315 · doi:10.1196/annals.1335.032 · PMID:15731321 · W2070805231
review OA: closed CC0 ⤵ 112 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review examines recent data on how inflammation associated with endometriosis affects fertility, noting elevated inflammatory mediators in women with the condition and reduced pregnancy rates in assisted reproductive technologies.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

A wealth of publications proposes that endometriosis and inflammation may have an unfavorable influence on fertility. A recent meta-analysis of assisted reproductive technologies demonstrated that, once confounding factors are controlled for, the pregnancy rate in women with endometriosis is approximately 50% of the rate of women with tubal factor infertility. Peritoneal fluid of women with endometriosis contains elevated amounts of macrophages and their secreted products, such as growth factors, cytokines, and angiogenic factors. Because reproductive organs are bathed in and thus will be influenced by peritoneal fluid, these proinflammatory mediators would affect various aspects of reproduction in women with endometriosis. Advanced stages of endometriosis may have easily understandable factors, such as distortion of the anatomy, causing infertility. On the other hand, in minimal or mild endometriosis mechanisms underlying reproductive failure are subtle and remain controversial. Recent reports suggest that inflammatory factors play a role in this endometriosis-associated reproductive failure. This review provides an overview of recent data on the effects of endometriosis-associated inflammation on fertility.

My notes (saved in your browser only)

Condition tags

mesh:D004716endometriosisinfertility

MeSH descriptors

Endometriosis Endometritis Infertility, Female Endometriosis Endometriosis Endometritis Endometritis Female Humans Infertility, Female Infertility, Female

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

Cited by (50)

Source provenance

crossref
last seen: 2026-06-25T06:34:01.660557+00:00
europepmc
last seen: 2026-07-28T06:14:09.330459+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:15:41.664291+00:00
unpaywall
last seen: 2026-07-28T06:55:22.213180+00:00
License: CC0 · commercial use OK