Endometriosis: Endometriosis and infertility: raised iron concentration in the peritoneal fluid and its effect on the acrosome reaction
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Endometriosis patients' peritoneal fluid showed increased iron and decreased sperm acrosome reaction rates, suggesting iron catalyzes damage to sperm function.
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Abstract
Endometriosis and infertility are commonly associated. This study investigated the role of accelerated lipid peroxidation of spermatozoa by the peritoneal fluid of patients with endometriosis as a cause for this association. It proposes that the increased iron concentration present in the fluid of these patients acts as a catalyst for the process. Peritoneal fluid from 25 patients with endometriosis and 25 matched controls was obtained at laparoscopy. Spermatozoa were incubated in the fluid from both groups and the subsequent acrosome reaction rates analysed. The relationship between these results and iron concentration in the fluid was examined. A significant decrease in the acrosome reaction rate was seen in the endometriotic group (P = 0.034). Overall, a decrease in the acrosome reaction rate was associated with an increased iron concentration in the fluid (18 of the 25 pairs). In mild disease, (six of 11 pairs), the relationship was not as marked as that in severe disease (12 of 14 pairs). These results suggest that the peritoneal fluid in patients with endometriosis has a detrimental action on the acrosome reaction of spermatozoa in vitro.
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Cited by (45)
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- Iron metabolism markers in peritoneal fluid of patients with endometriosis: systematic review and meta-analysis 2024
- Epidemiology of infertility in women with endometriosis 2024
- The Pathological Role of miRNAs in Endometriosis 2023
- The role of iron in the pathogenesis of endometriosis: a systematic review 2023
- Genomic Insults and their Redressal in the Eutopic Endometrium of Women with Endometriosis 2023
- Endometriosis-associated infertility: From pathophysiology to tailored treatment 2022
- Iron overload compromises preimplantation mouse embryo development 2021
- Iron overload in endometriosis peritoneal fluid induces early embryo ferroptosis mediated by HMOX1 2021
- Mast Cells in Peritoneal Fluid From Women With Endometriosis and Their Possible Role in Modulating Sperm Function 2020
- Peritoneal fluid from women with endometriosis impairs human spermatozoa functionality 2019
- Disrupted iron metabolism in peritoneal fluid may induce oxidative stress in the peritoneal cavity of women with endometriosis 2017
- Role of Iron in the Pathogenesis of Endometriosis 2015
- Dating Endometriotic Ovarian Cysts Based on the Content of Cyst Fluid and its Potential Clinical Implications 2015
- Comparison of Gonadotropin with Gonadotropin and Letrozole Combination in Infertile Women with Biopsy - Proven Endometriosis Undergoing Intracytoplasmic Sperm Injection 2014
- Effect of endometriosis on implantation rates when compared to tubal factor in fresh non donor in vitro fertilization cycles 2014
- Endometriosis and Angiogenic Factors 2012
- Principles of phenomics in endometriosis 2012
- The 'incessant menstruation' hypothesis: a mechanistic ovarian cancer model with implications for prevention 2011
- Involvement of Iron, Nuclear Factor-Kappa B (NF-κB) and Prostaglandins in the Pathogenesis of Peritoneal Endometriosis-Associated Inflammation: A Review 2009
- Involvement of iron, nuclear factor-kappa B (NF-KB) and prostaglandins in the pathogenesis of peritoneal endometriosis-associated inflammation: A review 2009
- Reproductive Surgery for Endometriosis-Associated Infertility 2008
- Iron storage is significantly increased in peritoneal macrophages of endometriosis patients and correlates with iron overload in peritoneal fluid 2008
- Paracrine regulation of endometriotic tissue 2007
- Iron overload enhances epithelial cell proliferation in endometriotic lesions induced in a murine model 2006
- Biologia della cellula endometriosica 2005
- Reduction of estrogen production by interleukin-6 in a human granulosa tumor cell line may have implications for endometriosis-associated infertility 2005
- Endometriosis and Inflammation in Infertility 2004
- Peritoneal fluid environment in endometriosis. Clinicopathological implications. 2003
- Peritoneal fluid environment in endometriosis 2003
- Atherosclerosis, Oxidation and Endometriosis 2002
- Iron overload in the peritoneal cavity of women with pelvic endometriosis 2002
- Macrophages, Oxidation, and Endometriosis 2002
- Oxidative stress and peritoneal endometriosis 2002
- Role of cytokines in endometriosis 2001
- Role of cytokines in endometriosis 2001
- Pathophysiology of Endometriosis-Associated Infertility 1999
- Peritoneal fluid modulates the sperm acrosomal exocytosis induced by N-acetylglucosaminyl neoglycoprotein 1999
- The relevance of the peritoneal fluid in endometriosis-associated infertility 1999
- Effect of peritoneal fluid from endometriosis patients on sperm motion characteristics and acrosome reaction. 1999
- Outcome of IVF in Patients with Endometriosis in Comparison with Tubal-Factor Infertility 1998
- Effects of Antibodies to Transferrin and Alpha 2‐HS Glycoprotein on In Vitro Sperm Motion: Implications in Infertility Associated with Endometriosis 1998
- Endometriosis-associated infertility 1997
- The peritoneal environment in endometriosis 1996
- Peritoneal fluid from women with moderate or severe endometriosis inhibits sperm motility: the role of seminal fluid components 1996
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