Role of Iron in the Pathogenesis of Endometriosis

Sajal Gupta, Avi Harlev, Ashok Agarwal, Sheila R. Gokul, Deepika Kumaresan
In: SpringerBriefs in Reproductive Biology · 2015 · pp. 37–48 · doi:10.1007/978-3-319-18308-4_5 · W2262040325
book-chapter OA: closed CC0 ⤵ 2 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-10 ⓘ

Iron accumulates in endometriosis through erythrocyte phagocytosis and subsequent heme processing, leading to iron overload that dysregulates gene expression and causes oxidative stress.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

The paper reviews how iron may contribute to endometriosis pathogenesis by accumulating in peritoneal fluid, macrophages, and endometrial lesions after erythrocyte phagocytosis, leading to hemoglobin release and free iron generation via pathways such as haptoglobin binding or hemeoxygenase-1. Free iron is proposed to be taken up by ferritin and transferrin, promoting iron buildup in macrophages or lesions and dysregulating endometriosis-associated gene expression through oxidative stress. The main caveat is that this is a narrative chapter that synthesizes prior evidence rather than presenting new patient or experimental data. This paper is centrally about endometriosis — it focuses specifically on the role of iron in endometriosis development and related oxidative stress mechanisms.

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endometriosis

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last seen: 2026-06-10T17:14:06.276822+00:00
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