Peritoneal endometriotic lesions differentially express a haptoglobin-like gene*

Marta Piva, M Piva, K L Sharpe-Timms
Molecular human reproduction · 1999 · vol. 5(1) , pp. 71–78 · doi:10.1093/molehr/5.1.71 · PMID:10050665 · W2136649364
article OA: bronze CC0 ⤵ 24 in-corpus citations
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This study sequenced the endometriosis protein-I (ENDO-I) cDNA, finding 99.4% homology with human haptoglobin beta-chain, and demonstrated its significantly higher expression in peritoneal endometriotic lesions compared to peritoneum, endometrioma, and eutopic endometrium.

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Abstract

A unique glycoprotein, called endometriosis protein-I (ENDO-I), has previously been shown to be synthesized and secreted by rat and human endometriotic explants. Furthermore, the N-terminal amino acid sequence analysis showed that ENDO-I shares homology with haptoglobin. The present study was designed to determine this sequence of ENDO-I cDNA from human peritoneal endometriotic lesions and to determine the relative expression of the ENDO-I gene in several human tissues. Poly A-enriched RNA was isolated and reverse-transcribed. To determine the sequence of ENDO-I cDNA, a polymerase chain reaction was performed on cDNA from human endometriotic lesions and a gene-specific primer based on the human haptoglobin sequence. A similar procedure was followed to assess the relative expression of the ENDO-I gene in various tissues. Glyceraldehyde-3-phosphate-dehydrogenase was used as an internal control. ENDO-I gene expression was quantified by densitometry. Sequence analysis of ENDO-I cDNA identified 873 nucleotides that displayed 99.4% homology with the human haptoglobin beta-chain. Relative expression of ENDO-I mRNA by peritoneal endometriotic lesions was 19-fold greater than peritoneum, 28-fold greater than endometrioma and 37-fold greater than eutopic endometrium (P<0.01). Haptoglobin-like ENDO-I may be associated with localized angiogenesis and altered immune response involved with the aetiology/pathophysiology of endometriosis.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Endometriosis Glycoproteins Haptoglobins Peritoneal Diseases Adolescent Adult Animals Base Sequence Case-Control Studies Endometriosis Endometrium Endometrium Endometrium Female Gene Expression Regulation Glycoproteins Haptoglobins Humans Liver Liver

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